Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin

A. T. Lane, K. F. Helm, L. A. Goldsmith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Human fetal skin was evaluated for sequential and regional development of several epidermal antigens. Indirect immunofluorescent methods were used to detect laminin, bullous pemphigoid antigen, pemphigus antigen, and anchoring fibril antigens identified by monoclonal antibodies AF1 and AF2. Eighty-three human fetal skin biopsies from 32 human fetuses were examined. The fetuses examined ranged from estimated gestational age (EGA) of 7-38 weeks. Laminin was present in the basement membrane zone of all the fetal tissues examined. Bullous pemphigoid antigen developed first in the palm and sole, 9 weeks EGA, and was present in all other sites by 17 weeks EGA. Pemphigus antigen was present by 11 weeks EGA. AF1 and AF2 staining was not present until 26 weeks EGA. AF1 and AF2 stained epidermal basal cells in addition to the basement membrane zone area. Comparison of human fetal skin development with basal cell carcinoma identified similarities between basal cell carcinoma and early fetal development.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalJournal of Investigative Dermatology
Volume84
Issue number1
DOIs
StatePublished - Jan 1 1985

Fingerprint

Bullous Pemphigoid
Pemphigus
Laminin
Skin
Gestational Age
Antigens
Fetus
Basal Cell Carcinoma
Cells
Fetal Development
Basement Membrane
Biopsy
Monoclonal Antibodies
Tissue
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

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abstract = "Human fetal skin was evaluated for sequential and regional development of several epidermal antigens. Indirect immunofluorescent methods were used to detect laminin, bullous pemphigoid antigen, pemphigus antigen, and anchoring fibril antigens identified by monoclonal antibodies AF1 and AF2. Eighty-three human fetal skin biopsies from 32 human fetuses were examined. The fetuses examined ranged from estimated gestational age (EGA) of 7-38 weeks. Laminin was present in the basement membrane zone of all the fetal tissues examined. Bullous pemphigoid antigen developed first in the palm and sole, 9 weeks EGA, and was present in all other sites by 17 weeks EGA. Pemphigus antigen was present by 11 weeks EGA. AF1 and AF2 staining was not present until 26 weeks EGA. AF1 and AF2 stained epidermal basal cells in addition to the basement membrane zone area. Comparison of human fetal skin development with basal cell carcinoma identified similarities between basal cell carcinoma and early fetal development.",
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Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin. / Lane, A. T.; Helm, K. F.; Goldsmith, L. A.

In: Journal of Investigative Dermatology, Vol. 84, No. 1, 01.01.1985, p. 27-30.

Research output: Contribution to journalArticle

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