Identification of ellagic acid rhamnoside as a bioactive component of a complex botanical extract with anti-biofilm activity

Benjamin M. Fontaine, Kate Nelson, James T. Lyles, Parth B. Jariwala, Jennifer M. García-Rodriguez, Cassandra L. Quave, Emily E. Weinert

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Staphylococcus aureus is a leading cause of hospital-acquired infections. It is listed among the top "serious threats" to human health in the USA, due in large part to rising rates of resistance. Many S. aureus infections are recalcitrant to antibiotic therapy due to their ability to form a biofilm, which acts not only as a physical barrier to antibiotics and the immune system, but results in differences in metabolism that further restricts antibiotic efficacy. Development of a modular strategy to synthesize a library of phenolic glycosides allowed for bioactivity testing and identification of anti-biofilm compounds within an extract of the elmleaf blackberry (Rubus ulmifolius). Two ellagic acid (EA) derivatives, EA xyloside and EA rhamnoside, have been identified as components of the Rubus extract. In addition, EA rhamnoside has been identified as an inhibitor of biofilm formation, with activity comparable to the complex extract 220D-F2 (composed of a mixture of EA glycosides), and confirmed by confocal laser scanning microscopy analyses.

Original languageEnglish (US)
Article number496
JournalFrontiers in Microbiology
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 23 2017

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

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