Identification of novel exons from rat-mouse comparisons

Anton Nekrutenko

doi:10.1007/s00239-004-2653-4

Identification of novel exons from rat-mouse comparisons

Anton Nekrutenko

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.

Original language	English (US)
Pages (from-to)	703-708
Number of pages	6
Journal	Journal Of Molecular Evolution
Volume	59
Issue number	5
DOIs	https://doi.org/10.1007/s00239-004-2653-4
State	Published - Nov 1 2004

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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