Identification of novel exons from rat-mouse comparisons

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalJournal Of Molecular Evolution
Volume59
Issue number5
DOIs
StatePublished - Nov 1 2004

Fingerprint

exons
Rats
Exons
Genes
rodent
Rodentia
rodents
genome
gene
rats
mice
genes
Genome
Recombinant DNA
alternative splicing
Human Genome
comparison

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

@article{02ef17772ad5436faceb2d6cb2d052f3,
title = "Identification of novel exons from rat-mouse comparisons",
abstract = "Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.",
author = "Anton Nekrutenko",
year = "2004",
month = "11",
day = "1",
doi = "10.1007/s00239-004-2653-4",
language = "English (US)",
volume = "59",
pages = "703--708",
journal = "Journal of Molecular Evolution",
issn = "0022-2844",
publisher = "Springer New York",
number = "5",

}

Identification of novel exons from rat-mouse comparisons. / Nekrutenko, Anton.

In: Journal Of Molecular Evolution, Vol. 59, No. 5, 01.11.2004, p. 703-708.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Identification of novel exons from rat-mouse comparisons

AU - Nekrutenko, Anton

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.

AB - Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.

UR - http://www.scopus.com/inward/record.url?scp=12144263837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144263837&partnerID=8YFLogxK

U2 - 10.1007/s00239-004-2653-4

DO - 10.1007/s00239-004-2653-4

M3 - Article

C2 - 15693626

AN - SCOPUS:12144263837

VL - 59

SP - 703

EP - 708

JO - Journal of Molecular Evolution

JF - Journal of Molecular Evolution

SN - 0022-2844

IS - 5

ER -