Abstract
Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 703-708 |
| Number of pages | 6 |
| Journal | Journal Of Molecular Evolution |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 2004 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics
Cite this
}
Identification of novel exons from rat-mouse comparisons. / Nekrutenko, Anton.
In: Journal Of Molecular Evolution, Vol. 59, No. 5, 01.11.2004, p. 703-708.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of novel exons from rat-mouse comparisons
AU - Nekrutenko, Anton
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.
AB - Exon shuffling, a major mechanism of gene evolution, scrambles existing sequences to create new genes. However, is it possible for an exon to be created from scratch? Here we conduct a survey of rat and mouse genomes and identify 2,302 putative rodent-specific exons absent from the human genome. Analysis of rodent transcripts supporting these exons indicates that over half appear to be alternatively spliced in genes orthologous between rodents and human. This study demonstrates the importance of sequencing genomes from multiple species to accurately document the evolution of gene structure.
UR - http://www.scopus.com/inward/record.url?scp=12144263837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144263837&partnerID=8YFLogxK
U2 - 10.1007/s00239-004-2653-4
DO - 10.1007/s00239-004-2653-4
M3 - Article
C2 - 15693626
AN - SCOPUS:12144263837
VL - 59
SP - 703
EP - 708
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
SN - 0022-2844
IS - 5
ER -