Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo, Andrew Watson, James Kempson, Marianne Carlsen, Joseph Barbosa, Karen Stebbins, Deborah Lee, John Dodd, Steven G. Nadler, Murray McKinnon, Joel Barrish, William J. Pitts

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Abstract

A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.

Original languageEnglish (US)
Pages (from-to)1935-1938
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
DOIs
Publication statusPublished - Apr 1 2009

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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