Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

William J. Pitts, Wayne Vaccaro, Tram Huynh, Katerina Leftheris, Jacques Y. Roberge, Joseph Barbosa, Junqing Guo, Baerbel Brown, Andrew Watson, Karen Donaldson, Gary C. Starling, Peter A. Kiener, Michael A. Poss, John H. Dodd, Joel C. Barrish

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.

Original languageEnglish (US)
Pages (from-to)2955-2958
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number11
DOIs
StatePublished - Jun 7 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Identification of purine inhibitors of phosphodiesterase 7 (PDE7)'. Together they form a unique fingerprint.

  • Cite this

    Pitts, W. J., Vaccaro, W., Huynh, T., Leftheris, K., Roberge, J. Y., Barbosa, J., Guo, J., Brown, B., Watson, A., Donaldson, K., Starling, G. C., Kiener, P. A., Poss, M. A., Dodd, J. H., & Barrish, J. C. (2004). Identification of purine inhibitors of phosphodiesterase 7 (PDE7). Bioorganic and Medicinal Chemistry Letters, 14(11), 2955-2958. https://doi.org/10.1016/j.bmcl.2004.03.021