Identifying functional cis-acting regulatory modules of the yan gene in Drosophila melanogaster

Edward Ramos, Mitch Price, Margaret Rohrbaugh, Zhi Chun Lai

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Yan is a nuclear DNA-binding protein that acts as a general inhibitor of cellular differentiation and proliferation in Drosophila melanogaster. The genetic and biochemical mechanisms required for regulating Yan protein function are well understood, however, the molecular mechanism of yan gene transcriptional regulation has not been fully elucidated. Here we show that the dynamic expression of the yan gene is specified by distinct spatial and temporal cis-acting regulatory elements in embryos and larval tissues. Each of these distinct elements is thus capable of replicating vital aspects of endogenous yan gene expression.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalDevelopment Genes and Evolution
Volume213
Issue number2
DOIs
StatePublished - Mar 1 2003

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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