Identifying genetic markers of adaptation for surveillance of viral host jumps

Kim M. Pepin, Sandra Lass, Juliet R.C. Pulliam, Andrew Fraser Read, James O. Lloyd-Smith

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptations are required for host jumps and thus when predictive genetic markers may be present.

Original languageEnglish (US)
Pages (from-to)802-813
Number of pages12
JournalNature Reviews Microbiology
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2010

Fingerprint

Genetic Markers
Venezuelan Equine Encephalitis Viruses
Canine Parvovirus
Genetic Phenomena
Severe Acute Respiratory Syndrome
Coronavirus
Human Influenza
Viruses
Research
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Pepin, Kim M. ; Lass, Sandra ; Pulliam, Juliet R.C. ; Read, Andrew Fraser ; Lloyd-Smith, James O. / Identifying genetic markers of adaptation for surveillance of viral host jumps. In: Nature Reviews Microbiology. 2010 ; Vol. 8, No. 11. pp. 802-813.
@article{39a29db6c44d422691d955889237eeef,
title = "Identifying genetic markers of adaptation for surveillance of viral host jumps",
abstract = "Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptations are required for host jumps and thus when predictive genetic markers may be present.",
author = "Pepin, {Kim M.} and Sandra Lass and Pulliam, {Juliet R.C.} and Read, {Andrew Fraser} and Lloyd-Smith, {James O.}",
year = "2010",
month = "11",
day = "1",
doi = "10.1038/nrmicro2440",
language = "English (US)",
volume = "8",
pages = "802--813",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "11",

}

Identifying genetic markers of adaptation for surveillance of viral host jumps. / Pepin, Kim M.; Lass, Sandra; Pulliam, Juliet R.C.; Read, Andrew Fraser; Lloyd-Smith, James O.

In: Nature Reviews Microbiology, Vol. 8, No. 11, 01.11.2010, p. 802-813.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Identifying genetic markers of adaptation for surveillance of viral host jumps

AU - Pepin, Kim M.

AU - Lass, Sandra

AU - Pulliam, Juliet R.C.

AU - Read, Andrew Fraser

AU - Lloyd-Smith, James O.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptations are required for host jumps and thus when predictive genetic markers may be present.

AB - Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptations are required for host jumps and thus when predictive genetic markers may be present.

UR - http://www.scopus.com/inward/record.url?scp=77958113527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958113527&partnerID=8YFLogxK

U2 - 10.1038/nrmicro2440

DO - 10.1038/nrmicro2440

M3 - Review article

C2 - 20938453

AN - SCOPUS:77958113527

VL - 8

SP - 802

EP - 813

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 11

ER -