Idiopathic CD4+ T‐lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men

Thomas R. O'Brien, Laura Diamondstone, Michael W. Fried, Louis M. Aledort, Sabine Eichinger, M. Elaine Eyster, Margaret W. Hilgartner, Gilbert White, Adrian M. Di Bisceglie, James J. Goedert

    Research output: Contribution to journalArticle

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    Abstract

    Persons with hemophilia or other HIV‐1 risk factors may be more likely to have idiopathic CD4+ T‐lymphocytopenia (ICL). We determined the frequency of ICL in prospectively followed cohorts of HIV‐1 seronegative hemophilic men and seronegative female sex partners of HIV‐1 infected hemophilic men, and examined factors potentially associated with ICL. Seven of 304 (2.3%) seronegative hemophilic men and one of 160 (0.6%) female partners met the ICL definition, but the condition resolved for two of the men and for the sole female partner. All five men with persistent ICL had lymphocytopenia (<1,200 total lymphocytes/ül) and <300 total CD4+ lymphocytes/ü only one had a low CD4+ percent‐ age. On the most recent measurement, 14.5% of the 304 seronegative hemophilic men had lymphoctopenia. Compared with matched hemophilic controls, men with persistent ICL more often had a history of liver disease (3/5 cases, 0/21 controls, P = 0.007) or splenomegaly (3/5 cases, 4/21 controls; P = 0.04), but not severe hemophilia, greater clotting factor concentrate exposure, high alanine aminotransferase levels, hepatitis B virus antigenemia, or detectable hepatitis C virus RNA in plasma. All five cases and 20/21 controls had antibodies to hepatitis C virus present in their serum. In this cohort of hemophilic men, ICL was related to lymphocytopenia associated with liver disease rather than selective loss of CD4+ lymphocytes.

    Original languageEnglish (US)
    Pages (from-to)201-206
    Number of pages6
    JournalAmerican Journal of Hematology
    Volume49
    Issue number3
    DOIs
    StatePublished - Jan 1 1995

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    Hemophilia A
    HIV
    Lymphopenia
    Lymphocytes
    Liver Diseases
    Hepatitis C Antibodies
    Blood Coagulation Factors
    Splenomegaly
    Alanine Transaminase
    Hepatitis B virus
    Hepacivirus
    RNA
    Serum

    All Science Journal Classification (ASJC) codes

    • Hematology

    Cite this

    O'Brien, Thomas R. ; Diamondstone, Laura ; Fried, Michael W. ; Aledort, Louis M. ; Eichinger, Sabine ; Eyster, M. Elaine ; Hilgartner, Margaret W. ; White, Gilbert ; Di Bisceglie, Adrian M. ; Goedert, James J. / Idiopathic CD4+ T‐lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men. In: American Journal of Hematology. 1995 ; Vol. 49, No. 3. pp. 201-206.
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    title = "Idiopathic CD4+ T‐lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men",
    abstract = "Persons with hemophilia or other HIV‐1 risk factors may be more likely to have idiopathic CD4+ T‐lymphocytopenia (ICL). We determined the frequency of ICL in prospectively followed cohorts of HIV‐1 seronegative hemophilic men and seronegative female sex partners of HIV‐1 infected hemophilic men, and examined factors potentially associated with ICL. Seven of 304 (2.3{\%}) seronegative hemophilic men and one of 160 (0.6{\%}) female partners met the ICL definition, but the condition resolved for two of the men and for the sole female partner. All five men with persistent ICL had lymphocytopenia (<1,200 total lymphocytes/{\"u}l) and <300 total CD4+ lymphocytes/{\"u} only one had a low CD4+ percent‐ age. On the most recent measurement, 14.5{\%} of the 304 seronegative hemophilic men had lymphoctopenia. Compared with matched hemophilic controls, men with persistent ICL more often had a history of liver disease (3/5 cases, 0/21 controls, P = 0.007) or splenomegaly (3/5 cases, 4/21 controls; P = 0.04), but not severe hemophilia, greater clotting factor concentrate exposure, high alanine aminotransferase levels, hepatitis B virus antigenemia, or detectable hepatitis C virus RNA in plasma. All five cases and 20/21 controls had antibodies to hepatitis C virus present in their serum. In this cohort of hemophilic men, ICL was related to lymphocytopenia associated with liver disease rather than selective loss of CD4+ lymphocytes.",
    author = "O'Brien, {Thomas R.} and Laura Diamondstone and Fried, {Michael W.} and Aledort, {Louis M.} and Sabine Eichinger and Eyster, {M. Elaine} and Hilgartner, {Margaret W.} and Gilbert White and {Di Bisceglie}, {Adrian M.} and Goedert, {James J.}",
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    O'Brien, TR, Diamondstone, L, Fried, MW, Aledort, LM, Eichinger, S, Eyster, ME, Hilgartner, MW, White, G, Di Bisceglie, AM & Goedert, JJ 1995, 'Idiopathic CD4+ T‐lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men', American Journal of Hematology, vol. 49, no. 3, pp. 201-206. https://doi.org/10.1002/ajh.2830490305

    Idiopathic CD4+ T‐lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men. / O'Brien, Thomas R.; Diamondstone, Laura; Fried, Michael W.; Aledort, Louis M.; Eichinger, Sabine; Eyster, M. Elaine; Hilgartner, Margaret W.; White, Gilbert; Di Bisceglie, Adrian M.; Goedert, James J.

    In: American Journal of Hematology, Vol. 49, No. 3, 01.01.1995, p. 201-206.

    Research output: Contribution to journalArticle

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    AU - Diamondstone, Laura

    AU - Fried, Michael W.

    AU - Aledort, Louis M.

    AU - Eichinger, Sabine

    AU - Eyster, M. Elaine

    AU - Hilgartner, Margaret W.

    AU - White, Gilbert

    AU - Di Bisceglie, Adrian M.

    AU - Goedert, James J.

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    AB - Persons with hemophilia or other HIV‐1 risk factors may be more likely to have idiopathic CD4+ T‐lymphocytopenia (ICL). We determined the frequency of ICL in prospectively followed cohorts of HIV‐1 seronegative hemophilic men and seronegative female sex partners of HIV‐1 infected hemophilic men, and examined factors potentially associated with ICL. Seven of 304 (2.3%) seronegative hemophilic men and one of 160 (0.6%) female partners met the ICL definition, but the condition resolved for two of the men and for the sole female partner. All five men with persistent ICL had lymphocytopenia (<1,200 total lymphocytes/ül) and <300 total CD4+ lymphocytes/ü only one had a low CD4+ percent‐ age. On the most recent measurement, 14.5% of the 304 seronegative hemophilic men had lymphoctopenia. Compared with matched hemophilic controls, men with persistent ICL more often had a history of liver disease (3/5 cases, 0/21 controls, P = 0.007) or splenomegaly (3/5 cases, 4/21 controls; P = 0.04), but not severe hemophilia, greater clotting factor concentrate exposure, high alanine aminotransferase levels, hepatitis B virus antigenemia, or detectable hepatitis C virus RNA in plasma. All five cases and 20/21 controls had antibodies to hepatitis C virus present in their serum. In this cohort of hemophilic men, ICL was related to lymphocytopenia associated with liver disease rather than selective loss of CD4+ lymphocytes.

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