Idiopathic intracranial hypertension and transverse sinus stenosis: A modelling study

Scott A. Stevens, Michelle Previte, William D. Lakin, Nimish J. Thakore, Paul L. Penar, Brandon Hamschin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.

Original languageEnglish (US)
Pages (from-to)85-109
Number of pages25
JournalMathematical Medicine and Biology
Volume24
Issue number1
DOIs
StatePublished - Mar 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Pharmacology
  • Applied Mathematics

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