IgM MGUS associated with anti-MAG neuropathy: a single institution experience

Giampaolo Talamo, Muhammad A. Mir, Manoj K. Pandey, Jeffrey K. Sivik, Divisha Raheja

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Anti-MAG neuropathy is a very rare form of acquired polyneuropathy associated with IgM monoclonal gammopathy of undetermined significance (MGUS). We conducted a retrospective review of 194 consecutive MGUS patients seen at the Penn State Hershey Cancer Institute. We identified six patients among 37 (16 %) with IgM MGUS with anti-MAG neuropathy. Interestingly, an additional patient had anti-MAG neuropathy without MGUS. Common clinical manifestations were numbness and paresthesias of the extremities and gait imbalance. All four patients treated with rituximab and none of the three untreated ones had a subjective improvement of their symptoms. We conclude that all patients with IgM MGUS and neuropathy should be screened for anti-MAG antibodies and, if positive, they should be offered treatment with rituximab.

Original languageEnglish (US)
Pages (from-to)1011-1016
Number of pages6
JournalAnnals of Hematology
Volume94
Issue number6
DOIs
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Hematology

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