IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation

R. Paul Wilson, Shannon E. McGettigan, Van Duc Dang, Anil Kumar, Michael P. Cancro, Neda Nikbakht, William Stohl, Gudrun F. Debes

Research output: Contribution to journalArticle

Abstract

Antibodies are key to cutaneous host defense and inflammation. Despite their importance, the mechanisms by which skin antibodies are sustained are poorly described. Here, we identified that, in addition to antibody production in lymphoid tissues, plasma cells reside in healthy mouse and human skin. In naïve mice, IgM was the predominant isotype produced in skin. Skin plasma cells developed independently of T cells and microbiota. Importantly, chronic skin inflammation promoted the massive accumulation of IgM-secreting cells, and cutaneous immunization directed both T cell–dependent and –independent antigen-specific IgM-secreting cells into skin. Unlike their counterparts in lymphoid tissues, cutaneous IgM-secreting cells were completely dependent on survival factors such as a proliferation-inducing ligand or B cell–activating factor, which were constitutively expressed and upregulated during inflammation in skin. Our data support a model in which skin plasma cells supply natural and adaptive IgM to the cutaneous environment, thereby supporting homeostatic skin barrier functions and providing defense against pathogen intrusion. Our results are also of potential relevance for manipulation of cutaneous plasma cells in inflammatory skin diseases or cutaneous plasma cell malignancies.

Original languageEnglish (US)
Pages (from-to)2477-2487
Number of pages11
JournalJournal of Investigative Dermatology
Volume139
Issue number12
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Plasma Cells
Immunoglobulin M
Skin
Inflammation
Plasmas
Antibodies
T Independent Antigens
Lymphoid Tissue
Tissue
Immunization
T-cells
Pathogens
Microbiota
Cells
Ligands
Skin Diseases
Antibody Formation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Wilson, R. P., McGettigan, S. E., Dang, V. D., Kumar, A., Cancro, M. P., Nikbakht, N., ... Debes, G. F. (Accepted/In press). IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation. Journal of Investigative Dermatology, 139(12), 2477-2487. https://doi.org/10.1016/j.jid.2019.05.009
Wilson, R. Paul ; McGettigan, Shannon E. ; Dang, Van Duc ; Kumar, Anil ; Cancro, Michael P. ; Nikbakht, Neda ; Stohl, William ; Debes, Gudrun F. / IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation. In: Journal of Investigative Dermatology. 2019 ; Vol. 139, No. 12. pp. 2477-2487.
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Wilson, RP, McGettigan, SE, Dang, VD, Kumar, A, Cancro, MP, Nikbakht, N, Stohl, W & Debes, GF 2019, 'IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation', Journal of Investigative Dermatology, vol. 139, no. 12, pp. 2477-2487. https://doi.org/10.1016/j.jid.2019.05.009

IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation. / Wilson, R. Paul; McGettigan, Shannon E.; Dang, Van Duc; Kumar, Anil; Cancro, Michael P.; Nikbakht, Neda; Stohl, William; Debes, Gudrun F.

In: Journal of Investigative Dermatology, Vol. 139, No. 12, 12.2019, p. 2477-2487.

Research output: Contribution to journalArticle

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