Ikaros and tumor suppression in acute Lymphoblastic leukemia

Kimberly J. Payne, Sinisa Dovat

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalCritical Reviews in Oncogenesis
Volume16
Issue number1-2
DOIs
StatePublished - Jan 1 2011

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromatin Assembly and Disassembly
Zinc Fingers
Regulator Genes
Immune System
Signal Transduction
Neoplasms
Gene Expression
DNA
Genes
zinc-binding protein

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

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title = "Ikaros and tumor suppression in acute Lymphoblastic leukemia",
abstract = "The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function.",
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Ikaros and tumor suppression in acute Lymphoblastic leukemia. / Payne, Kimberly J.; Dovat, Sinisa.

In: Critical Reviews in Oncogenesis, Vol. 16, No. 1-2, 01.01.2011, p. 3-12.

Research output: Contribution to journalReview article

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