IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut

M. Manocha, M. S. Shajib, M. M. Rahman, H. Wang, P. Rengasamy, M. Bogunovic, M. Jordana, L. Mayer, W. I. Khan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Enterochromaffin (EC) cells in the gastrointestinal (GI) mucosa are the main source of serotonin (5-hydroxytryptamine (5-HT)) in the body. 5-HT is implicated in the pathophysiology of many GI disorders including functional and inflammatory bowel disorders. Herein we studied the role of interleukin 13 (IL-13) in EC cell biology by utilizing IL-13-deficient (IL-13-/-) mice and BON cells (a model for human EC cells). The numbers of EC cells and 5-HT amount were significantly lower in enteric parasite, Trichuris muris-infected IL-13-/- mice compared with the wild-type mice. This was accompanied with increased parasite burden in IL-13-/- mice. Treatment of naive and infected IL-13-/- mice with IL-13 increased EC cell numbers and 5-HT amount. BON cells expressed IL-13 receptor and in response to IL-13 produced more 5-HT. These results provide novel information on IL-13-mediated immunological control of 5-HT in the gut, which may ultimately lead to improved therapeutic opportunities in various GI disorders.

Original languageEnglish (US)
Pages (from-to)146-155
Number of pages10
JournalMucosal Immunology
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2013

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Enterochromaffin Cells
Interleukin-13
Hyperplasia
Serotonin
Parasites
Interleukin-13 Receptors
Trichuris
Gastrointestinal Diseases
Cell Biology
Mucous Membrane
Cell Count

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Manocha, M., Shajib, M. S., Rahman, M. M., Wang, H., Rengasamy, P., Bogunovic, M., ... Khan, W. I. (2013). IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut. Mucosal Immunology, 6(1), 146-155. https://doi.org/10.1038/mi.2012.58
Manocha, M. ; Shajib, M. S. ; Rahman, M. M. ; Wang, H. ; Rengasamy, P. ; Bogunovic, M. ; Jordana, M. ; Mayer, L. ; Khan, W. I. / IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut. In: Mucosal Immunology. 2013 ; Vol. 6, No. 1. pp. 146-155.
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Manocha, M, Shajib, MS, Rahman, MM, Wang, H, Rengasamy, P, Bogunovic, M, Jordana, M, Mayer, L & Khan, WI 2013, 'IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut', Mucosal Immunology, vol. 6, no. 1, pp. 146-155. https://doi.org/10.1038/mi.2012.58

IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut. / Manocha, M.; Shajib, M. S.; Rahman, M. M.; Wang, H.; Rengasamy, P.; Bogunovic, M.; Jordana, M.; Mayer, L.; Khan, W. I.

In: Mucosal Immunology, Vol. 6, No. 1, 01.01.2013, p. 146-155.

Research output: Contribution to journalArticle

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AU - Shajib, M. S.

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AU - Mayer, L.

AU - Khan, W. I.

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