IL-15 enhances survival and function of HIV-specific CD8+ T cells

Yvonne M. Mueller, Paul M. Bojczuk, E. Scott Halstead, Alfred H.J. Kim, James Witek, John D. Altman, Peter D. Katsikis

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

HIV-specific CD8+ T cells are prone to undergo apoptosis, and this may affect their ability to control HIV infection. Because CD8-mediated immune responses play a key role in controlling HIV infection, enhancing the survival and effector function of HIV-specific CD8+ T cells may augment their ability to control HIV virus. We show here that interleukin 15 (IL-15) potently inhibits spontaneous and CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells. IL-15 inhibits apoptosis in both CD45RA-CD62L- and CD45RA+CD62L- effector memory subpopulations of these cells. Furthermore, IL-15 greatly enhances the survival of HIV-specific CD8+ T cells in long-term cultures. Finally, IL-15 directly enhances activation, interferon γ(IFNγ) production, and direct ex vivo cytotoxicity of HIV-specific CD8+ T cells. Thus, IL-15 potently enhances the survival and effector function of HIV-specific CD8+ T cells and, therefore, may prove useful in augmenting the antiviral function of these cells.

Original languageEnglish (US)
Pages (from-to)1024-1029
Number of pages6
JournalBlood
Volume101
Issue number3
DOIs
StatePublished - Feb 1 2003

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Interleukin-15
T-cells
HIV
T-Lymphocytes
Apoptosis
Aptitude
HIV Infections
Cytotoxicity
Viruses
Cell culture
Interferons
Antiviral Agents
Chemical activation
Cells
Data storage equipment

All Science Journal Classification (ASJC) codes

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Mueller, Y. M., Bojczuk, P. M., Halstead, E. S., Kim, A. H. J., Witek, J., Altman, J. D., & Katsikis, P. D. (2003). IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood, 101(3), 1024-1029. https://doi.org/10.1182/blood-2002-07-1957
Mueller, Yvonne M. ; Bojczuk, Paul M. ; Halstead, E. Scott ; Kim, Alfred H.J. ; Witek, James ; Altman, John D. ; Katsikis, Peter D. / IL-15 enhances survival and function of HIV-specific CD8+ T cells. In: Blood. 2003 ; Vol. 101, No. 3. pp. 1024-1029.
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Mueller, YM, Bojczuk, PM, Halstead, ES, Kim, AHJ, Witek, J, Altman, JD & Katsikis, PD 2003, 'IL-15 enhances survival and function of HIV-specific CD8+ T cells', Blood, vol. 101, no. 3, pp. 1024-1029. https://doi.org/10.1182/blood-2002-07-1957

IL-15 enhances survival and function of HIV-specific CD8+ T cells. / Mueller, Yvonne M.; Bojczuk, Paul M.; Halstead, E. Scott; Kim, Alfred H.J.; Witek, James; Altman, John D.; Katsikis, Peter D.

In: Blood, Vol. 101, No. 3, 01.02.2003, p. 1024-1029.

Research output: Contribution to journalArticle

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Mueller YM, Bojczuk PM, Halstead ES, Kim AHJ, Witek J, Altman JD et al. IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood. 2003 Feb 1;101(3):1024-1029. https://doi.org/10.1182/blood-2002-07-1957