IL-17: A key player in the P. acnes inflammatory cascade?

Diane M. Thiboutot, Alison M. Layton, E. Anne Eady

Research output: Contribution to journalComment/debate

25 Citations (Scopus)

Abstract

Recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood mononuclear cells and present new evidence that IL-17+ cells are found in the perifollicular infiltrate of comedones. Additional studies are needed to assess the clinical relevance of IL-17 in acne.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalJournal of Investigative Dermatology
Volume134
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Interleukin-17
Acne Vulgaris
Microbial Interactions
Propionibacterium acnes
Skin Diseases
Blood Cells
Skin
Blood

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Thiboutot, Diane M. ; Layton, Alison M. ; Eady, E. Anne. / IL-17 : A key player in the P. acnes inflammatory cascade?. In: Journal of Investigative Dermatology. 2014 ; Vol. 134, No. 2. pp. 307-310.
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IL-17 : A key player in the P. acnes inflammatory cascade? / Thiboutot, Diane M.; Layton, Alison M.; Eady, E. Anne.

In: Journal of Investigative Dermatology, Vol. 134, No. 2, 01.01.2014, p. 307-310.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - IL-17

T2 - A key player in the P. acnes inflammatory cascade?

AU - Thiboutot, Diane M.

AU - Layton, Alison M.

AU - Eady, E. Anne

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood mononuclear cells and present new evidence that IL-17+ cells are found in the perifollicular infiltrate of comedones. Additional studies are needed to assess the clinical relevance of IL-17 in acne.

AB - Recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood mononuclear cells and present new evidence that IL-17+ cells are found in the perifollicular infiltrate of comedones. Additional studies are needed to assess the clinical relevance of IL-17 in acne.

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U2 - 10.1038/jid.2013.400

DO - 10.1038/jid.2013.400

M3 - Comment/debate

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VL - 134

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EP - 310

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

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