IL-2-inducible T-cell kinase (ITK) finds another (dance) partnery...TFII-I

Avery August

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)2354-2357
Number of pages4
JournalEuropean Journal of Immunology
Volume39
Issue number9
DOIs
StatePublished - Sep 1 2009

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Protein-Serine-Threonine Kinases
Allergy and Immunology
Protein-Tyrosine Kinases
T-Lymphocytes
Antigens
emt protein-tyrosine kinase
Tec protein-tyrosine kinase

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.",
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IL-2-inducible T-cell kinase (ITK) finds another (dance) partnery...TFII-I. / August, Avery.

In: European Journal of Immunology, Vol. 39, No. 9, 01.09.2009, p. 2354-2357.

Research output: Contribution to journalComment/debate

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T1 - IL-2-inducible T-cell kinase (ITK) finds another (dance) partnery...TFII-I

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AB - The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.

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