Image-Guided Focused Ultrasound for the Treatment of Bone Metastases

Current Status and Future Direction

Mark D. Hurwitz, Nicholas Zaorsky

Research output: Contribution to journalReview article

Abstract

Bone metastases are a pervasive problem in oncology. For many of these patients, pain due to osseous metastases is the predominant factor negatively influencing quality of life. High-intensity focused ultrasound (FUS) therapy is a novel technology used for the treatment of bone metastases. FUS can be done with either ultrasound or magnetic resonance guidance (USgFUS or MRgFUS respectively). We review the outcomes and toxicity of current studies using USgFUS and MRgFUS for the treatment of bone metastases. A recently completed phase III trial has confirmed statistically and clinically significant benefit in pain control and quality of life for patients with painful bone metastases who were not candidates for radiation therapy. Future areas of research include expansion of sites suitable for MRgFUS treatment, applicability of MRgFUS as a primary treatment for painful bone metastases either as standalone therapy or in combination with radiation, and development of conformal treatment devices.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalCurrent Radiology Reports
Volume1
Issue number2
DOIs
StatePublished - Jun 14 2013

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Neoplasm Metastasis
Bone and Bones
Therapeutics
Quality of Life
Pain
Direction compound
Magnetic Resonance Spectroscopy
Radiotherapy
Radiation
Technology
Equipment and Supplies
Research

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Bone metastases are a pervasive problem in oncology. For many of these patients, pain due to osseous metastases is the predominant factor negatively influencing quality of life. High-intensity focused ultrasound (FUS) therapy is a novel technology used for the treatment of bone metastases. FUS can be done with either ultrasound or magnetic resonance guidance (USgFUS or MRgFUS respectively). We review the outcomes and toxicity of current studies using USgFUS and MRgFUS for the treatment of bone metastases. A recently completed phase III trial has confirmed statistically and clinically significant benefit in pain control and quality of life for patients with painful bone metastases who were not candidates for radiation therapy. Future areas of research include expansion of sites suitable for MRgFUS treatment, applicability of MRgFUS as a primary treatment for painful bone metastases either as standalone therapy or in combination with radiation, and development of conformal treatment devices.",
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Image-Guided Focused Ultrasound for the Treatment of Bone Metastases : Current Status and Future Direction. / Hurwitz, Mark D.; Zaorsky, Nicholas.

In: Current Radiology Reports, Vol. 1, No. 2, 14.06.2013, p. 147-153.

Research output: Contribution to journalReview article

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