Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori, Walter E. Kaufmann, Christos Davatzikos, Bram Stieltjes, Laura Amodei, Kim Fredericksen, Godfrey D. Pearlson, Elias R. Melhem, Meiyappan Solaiyappan, Gerald Raymond, Hugo W. Moser, Peter C.M. Van Zijl

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalMagnetic Resonance in Medicine
Volume47
Issue number2
DOIs
StatePublished - Feb 12 2002

Fingerprint

Adrenoleukodystrophy
Neurodegenerative Diseases
Guidelines
Radiation
Brain

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Mori, S., Kaufmann, W. E., Davatzikos, C., Stieltjes, B., Amodei, L., Fredericksen, K., ... Van Zijl, P. C. M. (2002). Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magnetic Resonance in Medicine, 47(2), 215-223. https://doi.org/10.1002/mrm.10074
Mori, Susumu ; Kaufmann, Walter E. ; Davatzikos, Christos ; Stieltjes, Bram ; Amodei, Laura ; Fredericksen, Kim ; Pearlson, Godfrey D. ; Melhem, Elias R. ; Solaiyappan, Meiyappan ; Raymond, Gerald ; Moser, Hugo W. ; Van Zijl, Peter C.M. / Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. In: Magnetic Resonance in Medicine. 2002 ; Vol. 47, No. 2. pp. 215-223.
@article{249d802c4ffe45bf8c630dd33d477e5d,
title = "Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking",
abstract = "Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.",
author = "Susumu Mori and Kaufmann, {Walter E.} and Christos Davatzikos and Bram Stieltjes and Laura Amodei and Kim Fredericksen and Pearlson, {Godfrey D.} and Melhem, {Elias R.} and Meiyappan Solaiyappan and Gerald Raymond and Moser, {Hugo W.} and {Van Zijl}, {Peter C.M.}",
year = "2002",
month = "2",
day = "12",
doi = "10.1002/mrm.10074",
language = "English (US)",
volume = "47",
pages = "215--223",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

Mori, S, Kaufmann, WE, Davatzikos, C, Stieltjes, B, Amodei, L, Fredericksen, K, Pearlson, GD, Melhem, ER, Solaiyappan, M, Raymond, G, Moser, HW & Van Zijl, PCM 2002, 'Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking', Magnetic Resonance in Medicine, vol. 47, no. 2, pp. 215-223. https://doi.org/10.1002/mrm.10074

Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. / Mori, Susumu; Kaufmann, Walter E.; Davatzikos, Christos; Stieltjes, Bram; Amodei, Laura; Fredericksen, Kim; Pearlson, Godfrey D.; Melhem, Elias R.; Solaiyappan, Meiyappan; Raymond, Gerald; Moser, Hugo W.; Van Zijl, Peter C.M.

In: Magnetic Resonance in Medicine, Vol. 47, No. 2, 12.02.2002, p. 215-223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

AU - Mori, Susumu

AU - Kaufmann, Walter E.

AU - Davatzikos, Christos

AU - Stieltjes, Bram

AU - Amodei, Laura

AU - Fredericksen, Kim

AU - Pearlson, Godfrey D.

AU - Melhem, Elias R.

AU - Solaiyappan, Meiyappan

AU - Raymond, Gerald

AU - Moser, Hugo W.

AU - Van Zijl, Peter C.M.

PY - 2002/2/12

Y1 - 2002/2/12

N2 - Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

AB - Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=0036158378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036158378&partnerID=8YFLogxK

U2 - 10.1002/mrm.10074

DO - 10.1002/mrm.10074

M3 - Article

VL - 47

SP - 215

EP - 223

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -

Mori S, Kaufmann WE, Davatzikos C, Stieltjes B, Amodei L, Fredericksen K et al. Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magnetic Resonance in Medicine. 2002 Feb 12;47(2):215-223. https://doi.org/10.1002/mrm.10074