Imaging macrophages in trehalose with SIMS

S. A. Parry, M. E. Kurczy, X. Fan, M. S. Halleck, R. A. Schlegel, N. Winograd

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Phagocytosis is a major component of the animal immune system where apoptotic cellular material, metabolites, and waste are safely processed. Further, efficient phagocytosis by macrophages is key to maintaining healthy vascular systems and preventing atherosclerosis. Single-cell images of macrophage phagocytosis of red blood cells, RBCs, and polystyrene microspheres have been chemically mapped with TOF-SIMS. We demonstrate here cholesterol and phosphocholine localizations as relative to time and activity.

Original languageEnglish (US)
Pages (from-to)929-933
Number of pages5
JournalApplied Surface Science
Volume255
Issue number4
DOIs
StatePublished - Dec 15 2008

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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