Imaging macrophages in trehalose with SIMS

S. A. Parry, M. E. Kurczy, X. Fan, M. S. Halleck, R. A. Schlegel, Nicholas Winograd

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phagocytosis is a major component of the animal immune system where apoptotic cellular material, metabolites, and waste are safely processed. Further, efficient phagocytosis by macrophages is key to maintaining healthy vascular systems and preventing atherosclerosis. Single-cell images of macrophage phagocytosis of red blood cells, RBCs, and polystyrene microspheres have been chemically mapped with TOF-SIMS. We demonstrate here cholesterol and phosphocholine localizations as relative to time and activity.

Original languageEnglish (US)
Pages (from-to)929-933
Number of pages5
JournalApplied Surface Science
Volume255
Issue number4
DOIs
StatePublished - Dec 15 2008

Fingerprint

Trehalose
Macrophages
Secondary ion mass spectrometry
Imaging techniques
Phosphorylcholine
Immune system
Cholesterol
Polystyrenes
Metabolites
Microspheres
Animals
Blood
Cells

All Science Journal Classification (ASJC) codes

  • Surfaces, Coatings and Films

Cite this

Parry, S. A., Kurczy, M. E., Fan, X., Halleck, M. S., Schlegel, R. A., & Winograd, N. (2008). Imaging macrophages in trehalose with SIMS. Applied Surface Science, 255(4), 929-933. https://doi.org/10.1016/j.apsusc.2008.05.251
Parry, S. A. ; Kurczy, M. E. ; Fan, X. ; Halleck, M. S. ; Schlegel, R. A. ; Winograd, Nicholas. / Imaging macrophages in trehalose with SIMS. In: Applied Surface Science. 2008 ; Vol. 255, No. 4. pp. 929-933.
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Parry, SA, Kurczy, ME, Fan, X, Halleck, MS, Schlegel, RA & Winograd, N 2008, 'Imaging macrophages in trehalose with SIMS', Applied Surface Science, vol. 255, no. 4, pp. 929-933. https://doi.org/10.1016/j.apsusc.2008.05.251

Imaging macrophages in trehalose with SIMS. / Parry, S. A.; Kurczy, M. E.; Fan, X.; Halleck, M. S.; Schlegel, R. A.; Winograd, Nicholas.

In: Applied Surface Science, Vol. 255, No. 4, 15.12.2008, p. 929-933.

Research output: Contribution to journalArticle

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Parry SA, Kurczy ME, Fan X, Halleck MS, Schlegel RA, Winograd N. Imaging macrophages in trehalose with SIMS. Applied Surface Science. 2008 Dec 15;255(4):929-933. https://doi.org/10.1016/j.apsusc.2008.05.251