Imaging of Children with Cancer Predisposition Syndromes

Sudha A. Anupindi, Ethan A. Smith, Nancy Chauvin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Five to ten percent of all pediatric tumors are associated with a genetic predisposition. In this chapter, we will discuss the main imaging examinations used in the evaluation of specific cancer predisposition syndromes (CPS) including Wilms’ tumor predisposition syndromes, Li-Fraumeni syndrome, and neurofibromatosis type 1, as well as more rare syndromes that have specific features, including DICER1 mutations, familial paraganglioma syndromes, and multiple endocrine neoplasia syndromes. Currently, ultrasound (US) and whole-body MRI (WBMRI) are the main modalities utilized for tumor surveillance in these children with cancer predisposition syndromes. Contrast-enhanced ultrasound and WBMRI with positron emission tomography (PET) are emerging as adjunct imaging tools in oncological imaging. In our discussion, we will also highlight the advantages and limitations of US and WBMRI and emphasize the importance of expert imaging interpretation and appropriate communication to clinicians and families.

Original languageEnglish (US)
Title of host publicationPediatric Oncology
PublisherSpringer Verlag
Pages369-386
Number of pages18
DOIs
StatePublished - Jan 1 2019

Publication series

NamePediatric Oncology
ISSN (Print)1613-5318
ISSN (Electronic)2191-0812

Fingerprint

Neoplasms
Multiple Endocrine Neoplasia
Paraganglioma
Neurofibromatosis 1
Wilms Tumor
Genetic Predisposition to Disease
Positron-Emission Tomography
Communication
Pediatrics
Mutation
Sarcoma family syndrome of Li and Fraumeni

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Oncology

Cite this

Anupindi, S. A., Smith, E. A., & Chauvin, N. (2019). Imaging of Children with Cancer Predisposition Syndromes. In Pediatric Oncology (pp. 369-386). (Pediatric Oncology). Springer Verlag. https://doi.org/10.1007/978-3-030-03777-2_20
Anupindi, Sudha A. ; Smith, Ethan A. ; Chauvin, Nancy. / Imaging of Children with Cancer Predisposition Syndromes. Pediatric Oncology. Springer Verlag, 2019. pp. 369-386 (Pediatric Oncology).
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Anupindi, SA, Smith, EA & Chauvin, N 2019, Imaging of Children with Cancer Predisposition Syndromes. in Pediatric Oncology. Pediatric Oncology, Springer Verlag, pp. 369-386. https://doi.org/10.1007/978-3-030-03777-2_20

Imaging of Children with Cancer Predisposition Syndromes. / Anupindi, Sudha A.; Smith, Ethan A.; Chauvin, Nancy.

Pediatric Oncology. Springer Verlag, 2019. p. 369-386 (Pediatric Oncology).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Anupindi SA, Smith EA, Chauvin N. Imaging of Children with Cancer Predisposition Syndromes. In Pediatric Oncology. Springer Verlag. 2019. p. 369-386. (Pediatric Oncology). https://doi.org/10.1007/978-3-030-03777-2_20