Immune changes in test animals during spaceflight

A. T. Lesnyak, G. Sonnenfeld, M. P. Rykova, D. O. Meshkov, Andrea Marie Mastro, I. Konstantinova

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Over the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony- stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.

Original languageEnglish (US)
Pages (from-to)214-226
Number of pages13
JournalJournal of Leukocyte Biology
Volume54
Issue number3
DOIs
StatePublished - Jan 1 1993

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Space Flight
Astronauts
Colony-Stimulating Factors
Lymphocyte Activation
Natural Killer Cells
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology

Cite this

Lesnyak, A. T., Sonnenfeld, G., Rykova, M. P., Meshkov, D. O., Mastro, A. M., & Konstantinova, I. (1993). Immune changes in test animals during spaceflight. Journal of Leukocyte Biology, 54(3), 214-226. https://doi.org/10.1002/jlb.54.3.214
Lesnyak, A. T. ; Sonnenfeld, G. ; Rykova, M. P. ; Meshkov, D. O. ; Mastro, Andrea Marie ; Konstantinova, I. / Immune changes in test animals during spaceflight. In: Journal of Leukocyte Biology. 1993 ; Vol. 54, No. 3. pp. 214-226.
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Lesnyak, AT, Sonnenfeld, G, Rykova, MP, Meshkov, DO, Mastro, AM & Konstantinova, I 1993, 'Immune changes in test animals during spaceflight', Journal of Leukocyte Biology, vol. 54, no. 3, pp. 214-226. https://doi.org/10.1002/jlb.54.3.214

Immune changes in test animals during spaceflight. / Lesnyak, A. T.; Sonnenfeld, G.; Rykova, M. P.; Meshkov, D. O.; Mastro, Andrea Marie; Konstantinova, I.

In: Journal of Leukocyte Biology, Vol. 54, No. 3, 01.01.1993, p. 214-226.

Research output: Contribution to journalArticle

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Lesnyak AT, Sonnenfeld G, Rykova MP, Meshkov DO, Mastro AM, Konstantinova I. Immune changes in test animals during spaceflight. Journal of Leukocyte Biology. 1993 Jan 1;54(3):214-226. https://doi.org/10.1002/jlb.54.3.214