Immune complex levels in children with severe Plasmodium falciparum malaria

Erick K. Mibei, Alloys S.S. Orago, Josë A. Stoute

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Malaria infection leads to the formation of circulating immune complexes. However, it is unclear whether these complexes play a role in the pathogenesis of complicated Plasmodium falciparum malaria. This study aimed at determining if there are differences in the levels of immune complexes between children with severe malaria-associated anemia and cerebral malaria and between each of these two groups and their respective uncomplicated symptomatic malaria or healthy asymptomatic controls. Children with severe malaria-associated anemia and cerebral malaria had significantly higher immune complex levels than their respective controls, but there were no significant differences in the levels between the two severe malaria groups. In addition, there was an inverse relationship between the hemoglobin levels and immune complex levels in the severe anemia controls, suggesting that immune complexes may contribute to erythrocyte destruction in these children. These results suggest that immune complex levels alone cannot account for the differences in the distinct clinical presentation between severe malaria-associated anemia and cerebral malaria.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume72
Issue number5
DOIs
StatePublished - May 2005

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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