Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neoplasms

Muhammad Rizwan Khawaja, Robert P. Nelson, Nicholas Miller, Sunil S. Badve, Elizabeth Loehrer, Magdalena Czader, Susan M. Perkins, Kenneth Kesler, Patrick J. Loehrer

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Abstract

Introduction: This retrospective study aimed to characterize the clinical hematological and immunological features of patients with thymic epithelial neoplasms. Methods: From a cohort of 512 patients with thymic epithelial neoplasms, 79 patients diagnosed with autoimmune/immunodeficiency conditions or signs and/or symptoms suggesting an autoimmune or immunodeficiency state were evaluated by standard immunological and hematological testing. Results: Elevated percentages of CD2+, CD3+, and CD8+ lymphocytes were observed in 44 (57.1%), 33 (41.8%), and 32 (40.5%) patients. Low CD4+ and CD19+ percentages were observed in 25 (31.6%) and 36 (46.2%), respectively; CD4+:CD8+ ratios were inverted in 18 (22.8%). IgG, IgA, and IgM levels were low in 12 (15.8%), 9 (11.7%) and 15 (19.7%) patients, respectively. Patients with immunodeficiency condition(s) were more likely to have high CD8+ percentages (p=0.040), low CD19+ percentages (p=0.025), and/or inverted CD4+/CD8+ ratios (p=0.034). Patients with autoimmune condition(s) were more likely to have a high/normal CD4+ percentage (p=0.038). High CD2+ percentages were associated with lower mean IgG and IgA levels (p=0.030 and p=0.017, respectively). High CD3+ and CD8+ percentages were associated with lower mean IgA levels (p=0.046 and p=0.013, respectively). Low CD19+ percentages were associated with lower mean IgG and IgA levels (p=0.004 and p<0.001, respectively). Conclusion: Signs/symptoms and history of autoimmune and immunodeficiency conditions among patients with thymic epithelial neoplasms are associated with high frequencies of abnormalities in immunoglobulin levels and lymphocyte immunophenotypes, suggesting a role for their assessment.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalJournal of Clinical Immunology
Volume32
Issue number3
DOIs
StatePublished - Jun 1 2012

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Khawaja, M. R., Nelson, R. P., Miller, N., Badve, S. S., Loehrer, E., Czader, M., Perkins, S. M., Kesler, K., & Loehrer, P. J. (2012). Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neoplasms. Journal of Clinical Immunology, 32(3), 430-437. https://doi.org/10.1007/s10875-011-9644-1