Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential

Lauren J. Cator, Jose E. Pietri, Courtney C. Murdock, Johanna R. Ohm, Edwin E. Lewis, Andrew F. Read, Shirley Luckhart, Matthew B. Thomas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Malaria parasites alter mosquito feeding behaviour in a way that enhances parasite transmission. This is widely considered a prime example of manipulation of host behaviour to increase onward transmission, but transient immune challenge in the absence of parasites can induce the same behavioural phenotype. Here, we show that alterations in feeding behaviour depend on the timing and dose of immune challenge relative to blood ingestion and that these changes are functionally linked to changes in insulin signalling in the mosquito gut. These results suggest that altered phenotypes derive from insulin signalling-dependent host resource allocation among immunity, blood feeding, and reproduction in a manner that is not specific to malaria parasite infection. We measured large increases in mosquito survival and subsequent transmission potential when feeding patterns are altered. Leveraging these changes in physiology, behaviour and life history could promote effective and sustainable control of female mosquitoes responsible for transmission.

Original languageEnglish (US)
Article number11947
JournalScientific reports
Volume5
DOIs
StatePublished - Jul 8 2015

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Feeding Behavior
Culicidae
Malaria
Parasites
Insulin
Mosquito Control
Phenotype
Parasitic Diseases
Resource Allocation
Reproduction
Immunity
Eating

All Science Journal Classification (ASJC) codes

  • General

Cite this

Cator, Lauren J. ; Pietri, Jose E. ; Murdock, Courtney C. ; Ohm, Johanna R. ; Lewis, Edwin E. ; Read, Andrew F. ; Luckhart, Shirley ; Thomas, Matthew B. / Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential. In: Scientific reports. 2015 ; Vol. 5.
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Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential. / Cator, Lauren J.; Pietri, Jose E.; Murdock, Courtney C.; Ohm, Johanna R.; Lewis, Edwin E.; Read, Andrew F.; Luckhart, Shirley; Thomas, Matthew B.

In: Scientific reports, Vol. 5, 11947, 08.07.2015.

Research output: Contribution to journalArticle

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