Immune response of mice to the Thy 1.1 antigen: intra H 2 mapping of the complementary Ir Thy 1 loci

M. B. Zaleski, Jan Klein

Research output: Contribution to journalArticle

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Abstract

The primary immune response to the Thy 1.1 antigen was measured by a plaque assay that detected cells producing antibodies lytic for AKR thymocytes. F1 hybrids which were b/d heterozygous at the entire H 2 complex or at only some of its regions were studied. All F1 hybrids which were b/d heterozygotes at the K, IA and possibly IB regions displayed a complementary effect of the alleles at the Ir Thy 1A and Ir Thy 1B loci. The complementary effect was indicated by the significantly higher responses of the F1 hybrids than the responses of their parental strains. No complementary effect could be demonstrated in F1 hybrids which were b/d heterozygous at the IB IC, S and D regions, but not at the K and IA regions. The results excluded participation of the IC, S and D regions in the phenomenon of the complementation. Furthermore, one of the Ir Thy 1 loci could be mapped to the left of the IB subregion, most likely in the IA subregion of the H 2 complex. The second Ir Thy 1 locus could be mapped to the left of the IC subregion in either the IA or IB subregion.

Original languageEnglish (US)
Pages (from-to)814-817
Number of pages4
JournalJournal of Immunology
Volume117
Issue number3
StatePublished - Dec 1 1976

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Thy-1 Antigens
Antibody-Producing Cells
Thymocytes
Heterozygote
Alleles

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "The primary immune response to the Thy 1.1 antigen was measured by a plaque assay that detected cells producing antibodies lytic for AKR thymocytes. F1 hybrids which were b/d heterozygous at the entire H 2 complex or at only some of its regions were studied. All F1 hybrids which were b/d heterozygotes at the K, IA and possibly IB regions displayed a complementary effect of the alleles at the Ir Thy 1A and Ir Thy 1B loci. The complementary effect was indicated by the significantly higher responses of the F1 hybrids than the responses of their parental strains. No complementary effect could be demonstrated in F1 hybrids which were b/d heterozygous at the IB IC, S and D regions, but not at the K and IA regions. The results excluded participation of the IC, S and D regions in the phenomenon of the complementation. Furthermore, one of the Ir Thy 1 loci could be mapped to the left of the IB subregion, most likely in the IA subregion of the H 2 complex. The second Ir Thy 1 locus could be mapped to the left of the IC subregion in either the IA or IB subregion.",
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Immune response of mice to the Thy 1.1 antigen : intra H 2 mapping of the complementary Ir Thy 1 loci. / Zaleski, M. B.; Klein, Jan.

In: Journal of Immunology, Vol. 117, No. 3, 01.12.1976, p. 814-817.

Research output: Contribution to journalArticle

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AU - Klein, Jan

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