Syrian hamster la-like cell-surface glycoproteins have been identified by immunoprecipitation of radiolabeled hamster lymphocyte lysates with cross-reacting murine anti-Iak alloantisera. Two components of 39 000 and 29 000 daltons were discerned by polyacrylamide gel electrophoresis in SDS (SDS-PAGE). Absorption of the antisera with mouse or hamster lymphoid cells demonstrated the cross-reactive anti-Iak antibodies to be specific for hamster Ia homologues. These molecules were also shown to have radiolabeling characteristics similar to Ia antigens of the mouse and guinea pig. These studies suggest that distinct structural similarities exist between murine Ia and the hamster Ia-like molecules described here. In view of our previous immunochemical description of putative hamster class I homologues, the current identification of hamster class II homologues suggests that an adequate and contemporary description of the hamster major histocompatibility complex is possible and likely.
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