Immunogenetic Analysis of H‐2 Mutations: IV. Mapping of and Immune Reactions to the H‐2 fa Mutation

Jan Klein, I. K. EGOROV, Y. A. MNATSAKANYAN, V. HAUPTFELD

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

H‐2 fa is a spontaneous mutation that occurred in an (A.CA × A)F 1 female mouse and was later transferred on an A‐strain background [congenic line A.CA(M506) or M506]. Skin grafts exchanged between M506 and A.CA strains are rejected within 4 weeks after grafting. Significant reaction is observed when these two strains are used as responders and stimulators in mixed lymphocyte culture or in a splenomegaly graft‐versus‐host assay. The mutant antigen induces strong cell‐mediated lymphocytotoxicity. The mutation maps in the K end of the H‐2 complex. The capacity of mutant antigens to induce relatively strong lymphocyte proliferation is explained by hypothesizing that the T‐cell receptors reacting with K‐ or D‐region products can more easily recognize subtle than drastic alloantigenic differences.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalScandinavian Journal of Immunology
Volume5
Issue number5
DOIs
StatePublished - Jan 1 1976

All Science Journal Classification (ASJC) codes

  • Immunology

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