Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass

Craig S. Boutlis, Peter K. Fagan, D. Channe Gowda, Moses Lagog, Charles S. Mgone, Moses J. Bockarie, Nicholas M. Anstey

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The induction of neutralizing immunity to Plasmodium falciparum toxins by vaccination has been proposed as a preventive strategy to limit the severity of malaria. For this approach to be successful, generation of a sustained immune response would be necessary. This study shows that immunoglobulin G (IgG)-subclass responses elicited by the proposed P. falciparum toxin glycosylphosphatidylinositol (GPI) in Papua New Guinean subjects 5-60 years old predominantly involve IgG3, with a lesser contribution from IgG1 and an absence of IgG2 and IgG4. IgG3 levels declined sharply within 6 weeks of pharmacological clearance of parasitemia in all subjects, whereas a significant decrease in IgG1 levels was seen only in subjects ≤19 years old. Because the natural antibody response to P. falciparum GPIs is skewed toward the short-lived IgG3 subclass, a vaccination strategy with GPI analogues would likely require augmentation by costimulatory molecules, to induce a more persistent anti-GPI response.

Original languageEnglish (US)
Pages (from-to)862-865
Number of pages4
JournalJournal of Infectious Diseases
Volume187
Issue number5
DOIs
StatePublished - Mar 1 2003

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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