Immunoglobulin G Immunosuppression of Multiple Sclerosis: Suppression of All Three Major Lymphocyte Subsets

Richard Tenser, Kathleen A. Hay, Judith A. Aberg

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalArchives of Neurology
Volume50
Issue number4
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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