Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature

Mohammad Bilal, Abhishek Gulati, Kofi Clarke

Research output: Contribution to journalArticle

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Abstract

Background and aims: IgG4-mediated pouchitis was first described in 2011. The aetiology and pathogenesis of IgG4-associated pouchitis is unknown. Over the last four years, less than seventy cases of IgG-associated pouchitis have been reported from a pouchitis clinic in Cleveland. Methods: We report the first two cases of IgG4-associated pouchitis from our inflammatory bowel disease clinic and outside of Cleveland. Conclusion: This highlights the fact that this entity could be more common than we think. It is important for general gastroenterologists to think about IgG4-mediated disease if the patient has refractory pouchitis, so early diagnosis and referral can be made. This would avoid the cost of expensive therapy and minimize antibiotic use which is what happened in our cases prior to this diagnosis being made.

Original languageEnglish (US)
Pages (from-to)817-819
Number of pages3
JournalDigestive and Liver Disease
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2016

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Pouchitis
Immunoglobulins
Inflammatory Bowel Diseases
Early Diagnosis
Referral and Consultation
Immunoglobulin G
Anti-Bacterial Agents
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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title = "Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature",
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Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature. / Bilal, Mohammad; Gulati, Abhishek; Clarke, Kofi.

In: Digestive and Liver Disease, Vol. 48, No. 7, 01.07.2016, p. 817-819.

Research output: Contribution to journalArticle

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AB - Background and aims: IgG4-mediated pouchitis was first described in 2011. The aetiology and pathogenesis of IgG4-associated pouchitis is unknown. Over the last four years, less than seventy cases of IgG-associated pouchitis have been reported from a pouchitis clinic in Cleveland. Methods: We report the first two cases of IgG4-associated pouchitis from our inflammatory bowel disease clinic and outside of Cleveland. Conclusion: This highlights the fact that this entity could be more common than we think. It is important for general gastroenterologists to think about IgG4-mediated disease if the patient has refractory pouchitis, so early diagnosis and referral can be made. This would avoid the cost of expensive therapy and minimize antibiotic use which is what happened in our cases prior to this diagnosis being made.

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