Immunohistochemical acid phosphatase level and tumor grade in prostatic carcinoma

M. S. Bentz, C. Cohen, Laurence Demers, L. R. Budgeon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An immunoperoxidase technique to detect prostatic-specific acid phosphatase (PSAP) was used on specimens from 98 cases of prostatic carcinoma that were graded by both the Gleason and the Mostofi systems, to see if tumor grade correlated wtih amount of PSAP seen in tissue. Most tumors showed strong, diffuse cytoplasmic staining; no significant difference was seen among the various grades. Other than focal, weak staining of renal tubular epithelium, the antibody to PSAP gave uniformly negative results with a variety of normal and neoplastic tissues. In light of the great sensitivity and specificity of this technique, its potential applications include diagnosis of poorly differentiated prostatic malignant neoplasms, whether primary or metastatic.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume106
Issue number9
StatePublished - Jan 1 1982

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Acid Phosphatase
Carcinoma
Staining and Labeling
Photophobia
Neoplasms
Immunoenzyme Techniques
Prostatic Neoplasms
Epithelium
Kidney
Sensitivity and Specificity
Antibodies
prostatic acid phosphatase

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Bentz, M. S. ; Cohen, C. ; Demers, Laurence ; Budgeon, L. R. / Immunohistochemical acid phosphatase level and tumor grade in prostatic carcinoma. In: Archives of Pathology and Laboratory Medicine. 1982 ; Vol. 106, No. 9. pp. 476-480.
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Bentz, MS, Cohen, C, Demers, L & Budgeon, LR 1982, 'Immunohistochemical acid phosphatase level and tumor grade in prostatic carcinoma', Archives of Pathology and Laboratory Medicine, vol. 106, no. 9, pp. 476-480.

Immunohistochemical acid phosphatase level and tumor grade in prostatic carcinoma. / Bentz, M. S.; Cohen, C.; Demers, Laurence; Budgeon, L. R.

In: Archives of Pathology and Laboratory Medicine, Vol. 106, No. 9, 01.01.1982, p. 476-480.

Research output: Contribution to journalArticle

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