Immunohistochemical demonstration of prostatic origin of metastases

Michael S. Bentz; Cynthia Cohen; Laurence M. Demers; Lynn R. Budgeon

doi:10.1016/0090-4295(82)90004-8

Immunohistochemical demonstration of prostatic origin of metastases

Michael S. Bentz, Cynthia Cohen, Laurence M. Demers, Lynn R. Budgeon

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

An immunoperoxidase technique for prostate specific acid phosphatase was performed on 14 lymph node metastases of prostatic carcinoma and 13 cases of metastatic adenocarcinoma from other primary sites. Eleven metastatic prostate carcinomas showed diffuse strongly positive immunostain and one showed focal weak positivity. Two prostatic and all other metastatic carcinomas were negative. Thus, the method is found to be extremely specific (100 per cent) and to show a high degree of sensitivity (86 per cent) for the demonstration of the prostatic origin of lymph node metastases.

Original language	English (US)
Pages (from-to)	584-586
Number of pages	3
Journal	Urology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/0090-4295(82)90004-8
Publication status	Published - Jun 1982

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All Science Journal Classification (ASJC) codes

Urology

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Bentz, M. S., Cohen, C., Demers, L. M., & Budgeon, L. R. (1982). Immunohistochemical demonstration of prostatic origin of metastases. Urology, 19(6), 584-586. https://doi.org/10.1016/0090-4295(82)90004-8

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abstract = "An immunoperoxidase technique for prostate specific acid phosphatase was performed on 14 lymph node metastases of prostatic carcinoma and 13 cases of metastatic adenocarcinoma from other primary sites. Eleven metastatic prostate carcinomas showed diffuse strongly positive immunostain and one showed focal weak positivity. Two prostatic and all other metastatic carcinomas were negative. Thus, the method is found to be extremely specific (100 per cent) and to show a high degree of sensitivity (86 per cent) for the demonstration of the prostatic origin of lymph node metastases.",

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AB - An immunoperoxidase technique for prostate specific acid phosphatase was performed on 14 lymph node metastases of prostatic carcinoma and 13 cases of metastatic adenocarcinoma from other primary sites. Eleven metastatic prostate carcinomas showed diffuse strongly positive immunostain and one showed focal weak positivity. Two prostatic and all other metastatic carcinomas were negative. Thus, the method is found to be extremely specific (100 per cent) and to show a high degree of sensitivity (86 per cent) for the demonstration of the prostatic origin of lymph node metastases.

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10.1016/0090-4295(82)90004-8