Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners

Detlev Jung, Peter A. Berg, Lutz Edler, Wolfram Ehrenthal, Dietrich Fenner, Dieter Flesch-Janys, Christoph Huber, Reinhild Klein, Christina Koitka, George Lucier, Alfred Manz, Axel Muttray, Larry Needham, Olaf Päpke, Michael Pietsch, Christopher Portier, Donald George Jr Patterson, Winfried Prellwitz, Dirk M. Rose, Anne ThewsJohannes Konietzko

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

One hundred ninety-two workers in a German pesticide factory who were exposed to polychlorinated dibenzodioxins and -furans (PCDD/PCDF) were investigated for former and present diseases and laboratory changes of the immune system. Moreover, in a subgroup of 29 highly exposed and 28 control persons, proliferation studies were performed. In addition to assays such as blood count, immunoglobulins, serum electrophoresis, monoclonal bands, surface markers, autoantibodies, and lymphocyte proliferation, two new methods, the rise of tetanus antibody concentration after vaccination and the in vitro resistance of lymphocytes to chromate, were used to diagnose the morphologic and functional state of the immune system. There was no stringent correlation of actual PCDD/PCDF concentrations with the occurrence of infections or with one of the immune parameters. In addition, outcomes of the tetanus vaccination and the chromate resistance test were not correlated with PCDD/PCDF. However, the chromate resistance of lymphocytes stimulated by phytohemagglutinin of highly exposed persons was significantly lower than that for the control group. These findings indicate that the function of lymphocytes can be stressed and possibly impaired by high exposure to PCDD/PCDF.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalEnvironmental health perspectives
Volume106
Issue numberSUPPL. 2
StatePublished - Jun 16 1998

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Lymphocytes
Tetanus
Immune System
Vaccination
Furans
Chromates
Phytohemagglutinins
Pesticides
Autoantibodies
Electrophoresis
Immunoglobulins
Polychlorinated Dibenzodioxins
Control Groups
Antibodies
Infection
Serum
Chromate Resistance
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Jung, D., Berg, P. A., Edler, L., Ehrenthal, W., Fenner, D., Flesch-Janys, D., ... Konietzko, J. (1998). Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners. Environmental health perspectives, 106(SUPPL. 2), 689-695.
Jung, Detlev ; Berg, Peter A. ; Edler, Lutz ; Ehrenthal, Wolfram ; Fenner, Dietrich ; Flesch-Janys, Dieter ; Huber, Christoph ; Klein, Reinhild ; Koitka, Christina ; Lucier, George ; Manz, Alfred ; Muttray, Axel ; Needham, Larry ; Päpke, Olaf ; Pietsch, Michael ; Portier, Christopher ; Patterson, Donald George Jr ; Prellwitz, Winfried ; Rose, Dirk M. ; Thews, Anne ; Konietzko, Johannes. / Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners. In: Environmental health perspectives. 1998 ; Vol. 106, No. SUPPL. 2. pp. 689-695.
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title = "Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners",
abstract = "One hundred ninety-two workers in a German pesticide factory who were exposed to polychlorinated dibenzodioxins and -furans (PCDD/PCDF) were investigated for former and present diseases and laboratory changes of the immune system. Moreover, in a subgroup of 29 highly exposed and 28 control persons, proliferation studies were performed. In addition to assays such as blood count, immunoglobulins, serum electrophoresis, monoclonal bands, surface markers, autoantibodies, and lymphocyte proliferation, two new methods, the rise of tetanus antibody concentration after vaccination and the in vitro resistance of lymphocytes to chromate, were used to diagnose the morphologic and functional state of the immune system. There was no stringent correlation of actual PCDD/PCDF concentrations with the occurrence of infections or with one of the immune parameters. In addition, outcomes of the tetanus vaccination and the chromate resistance test were not correlated with PCDD/PCDF. However, the chromate resistance of lymphocytes stimulated by phytohemagglutinin of highly exposed persons was significantly lower than that for the control group. These findings indicate that the function of lymphocytes can be stressed and possibly impaired by high exposure to PCDD/PCDF.",
author = "Detlev Jung and Berg, {Peter A.} and Lutz Edler and Wolfram Ehrenthal and Dietrich Fenner and Dieter Flesch-Janys and Christoph Huber and Reinhild Klein and Christina Koitka and George Lucier and Alfred Manz and Axel Muttray and Larry Needham and Olaf P{\"a}pke and Michael Pietsch and Christopher Portier and Patterson, {Donald George Jr} and Winfried Prellwitz and Rose, {Dirk M.} and Anne Thews and Johannes Konietzko",
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Jung, D, Berg, PA, Edler, L, Ehrenthal, W, Fenner, D, Flesch-Janys, D, Huber, C, Klein, R, Koitka, C, Lucier, G, Manz, A, Muttray, A, Needham, L, Päpke, O, Pietsch, M, Portier, C, Patterson, DGJ, Prellwitz, W, Rose, DM, Thews, A & Konietzko, J 1998, 'Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners', Environmental health perspectives, vol. 106, no. SUPPL. 2, pp. 689-695.

Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners. / Jung, Detlev; Berg, Peter A.; Edler, Lutz; Ehrenthal, Wolfram; Fenner, Dietrich; Flesch-Janys, Dieter; Huber, Christoph; Klein, Reinhild; Koitka, Christina; Lucier, George; Manz, Alfred; Muttray, Axel; Needham, Larry; Päpke, Olaf; Pietsch, Michael; Portier, Christopher; Patterson, Donald George Jr; Prellwitz, Winfried; Rose, Dirk M.; Thews, Anne; Konietzko, Johannes.

In: Environmental health perspectives, Vol. 106, No. SUPPL. 2, 16.06.1998, p. 689-695.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners

AU - Jung, Detlev

AU - Berg, Peter A.

AU - Edler, Lutz

AU - Ehrenthal, Wolfram

AU - Fenner, Dietrich

AU - Flesch-Janys, Dieter

AU - Huber, Christoph

AU - Klein, Reinhild

AU - Koitka, Christina

AU - Lucier, George

AU - Manz, Alfred

AU - Muttray, Axel

AU - Needham, Larry

AU - Päpke, Olaf

AU - Pietsch, Michael

AU - Portier, Christopher

AU - Patterson, Donald George Jr

AU - Prellwitz, Winfried

AU - Rose, Dirk M.

AU - Thews, Anne

AU - Konietzko, Johannes

PY - 1998/6/16

Y1 - 1998/6/16

N2 - One hundred ninety-two workers in a German pesticide factory who were exposed to polychlorinated dibenzodioxins and -furans (PCDD/PCDF) were investigated for former and present diseases and laboratory changes of the immune system. Moreover, in a subgroup of 29 highly exposed and 28 control persons, proliferation studies were performed. In addition to assays such as blood count, immunoglobulins, serum electrophoresis, monoclonal bands, surface markers, autoantibodies, and lymphocyte proliferation, two new methods, the rise of tetanus antibody concentration after vaccination and the in vitro resistance of lymphocytes to chromate, were used to diagnose the morphologic and functional state of the immune system. There was no stringent correlation of actual PCDD/PCDF concentrations with the occurrence of infections or with one of the immune parameters. In addition, outcomes of the tetanus vaccination and the chromate resistance test were not correlated with PCDD/PCDF. However, the chromate resistance of lymphocytes stimulated by phytohemagglutinin of highly exposed persons was significantly lower than that for the control group. These findings indicate that the function of lymphocytes can be stressed and possibly impaired by high exposure to PCDD/PCDF.

AB - One hundred ninety-two workers in a German pesticide factory who were exposed to polychlorinated dibenzodioxins and -furans (PCDD/PCDF) were investigated for former and present diseases and laboratory changes of the immune system. Moreover, in a subgroup of 29 highly exposed and 28 control persons, proliferation studies were performed. In addition to assays such as blood count, immunoglobulins, serum electrophoresis, monoclonal bands, surface markers, autoantibodies, and lymphocyte proliferation, two new methods, the rise of tetanus antibody concentration after vaccination and the in vitro resistance of lymphocytes to chromate, were used to diagnose the morphologic and functional state of the immune system. There was no stringent correlation of actual PCDD/PCDF concentrations with the occurrence of infections or with one of the immune parameters. In addition, outcomes of the tetanus vaccination and the chromate resistance test were not correlated with PCDD/PCDF. However, the chromate resistance of lymphocytes stimulated by phytohemagglutinin of highly exposed persons was significantly lower than that for the control group. These findings indicate that the function of lymphocytes can be stressed and possibly impaired by high exposure to PCDD/PCDF.

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Jung D, Berg PA, Edler L, Ehrenthal W, Fenner D, Flesch-Janys D et al. Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners. Environmental health perspectives. 1998 Jun 16;106(SUPPL. 2):689-695.