Immunoreactive Met-Enkephalin in the Canine Adrenal; Response to Acute Hypovolemic Stress

Leo D. Farrell, Timothy S. Harrison, Laurence M. Demers

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Immunoreactive met-enkephalin was measured in the adrenal, kidney, liver, and intestine of the dog using radioimmunoassay. Adrenal tissue concentrations were 20 to 200-fold higher than the other tissues studied. In response to acute hypovolemic stress, the concentration of met-enkephalin in the adrenal vein of the dog increased 6-fold over basal peripheral arterial levels. These results suggest that the canine adrenal gland is a rich source of this opioid peptide and that the adrenal releases met-enkephalin in response to acute stress.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume173
Issue number4
DOIs
StatePublished - Sep 1983

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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