Immunosuppression and human cancer: Role of prostaglandins

Harold Harvey, Joseph C. Allegra, Laurence Demers, John R. Luderer, Dean E. Brenner, Joseph J. Trautlein, Deborah S. White, Marilyn A. Gillin, Allan Lipton

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Prostaglandins, unsaturated fatty acid derivatives with diversified pharmacologic activity, have been implicated in the pathophysiology of many diseases. Prostaglandin E (PGE) levels were measured by radioimmunoassay in the plasma of 41 normocalcemic patients with various stages of malignancies. Delayed hypersensitivity was assessed by a battery of six recall skin test antigens (ST) and by Dinitrochlorobenzene (DNCB) sensitization and challenge. Twenty‐five patients with one or more positive skin tests had a mean PGE level of 87 ± 8 pg/ml, whereas 16 patients with negative ST had a mean PGE level of 96 ± 12 pg/ml. Twenty‐one DNCB negative patients had a mean PGE level of 98 ± 12 pg/ml and eight totally anergic patients had a mean PGE of 96 ± 12 pg/ml. All PGE values were within the normal range and there was no statistical difference between the four groups, (p < 0.1). We concluded that circulating PGE does not correlate with the non‐specific immunosuppression seen in cancer patients.

Original languageEnglish (US)
Pages (from-to)2362-2364
Number of pages3
JournalCancer
Volume39
Issue number6
DOIs
StatePublished - Jan 1 1977

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Prostaglandins E
Immunosuppression
Prostaglandins
Skin Tests
Neoplasms
Dinitrochlorobenzene
Antigens
Delayed Hypersensitivity
Unsaturated Fatty Acids
Radioimmunoassay
Reference Values

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Harvey, H., Allegra, J. C., Demers, L., Luderer, J. R., Brenner, D. E., Trautlein, J. J., ... Lipton, A. (1977). Immunosuppression and human cancer: Role of prostaglandins. Cancer, 39(6), 2362-2364. https://doi.org/10.1002/1097-0142(197706)39:6<2362::AID-CNCR2820390608>3.0.CO;2-U
Harvey, Harold ; Allegra, Joseph C. ; Demers, Laurence ; Luderer, John R. ; Brenner, Dean E. ; Trautlein, Joseph J. ; White, Deborah S. ; Gillin, Marilyn A. ; Lipton, Allan. / Immunosuppression and human cancer : Role of prostaglandins. In: Cancer. 1977 ; Vol. 39, No. 6. pp. 2362-2364.
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Harvey, H, Allegra, JC, Demers, L, Luderer, JR, Brenner, DE, Trautlein, JJ, White, DS, Gillin, MA & Lipton, A 1977, 'Immunosuppression and human cancer: Role of prostaglandins', Cancer, vol. 39, no. 6, pp. 2362-2364. https://doi.org/10.1002/1097-0142(197706)39:6<2362::AID-CNCR2820390608>3.0.CO;2-U

Immunosuppression and human cancer : Role of prostaglandins. / Harvey, Harold; Allegra, Joseph C.; Demers, Laurence; Luderer, John R.; Brenner, Dean E.; Trautlein, Joseph J.; White, Deborah S.; Gillin, Marilyn A.; Lipton, Allan.

In: Cancer, Vol. 39, No. 6, 01.01.1977, p. 2362-2364.

Research output: Contribution to journalArticle

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AU - Trautlein, Joseph J.

AU - White, Deborah S.

AU - Gillin, Marilyn A.

AU - Lipton, Allan

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Y1 - 1977/1/1

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Harvey H, Allegra JC, Demers L, Luderer JR, Brenner DE, Trautlein JJ et al. Immunosuppression and human cancer: Role of prostaglandins. Cancer. 1977 Jan 1;39(6):2362-2364. https://doi.org/10.1002/1097-0142(197706)39:6<2362::AID-CNCR2820390608>3.0.CO;2-U