Immunosuppressive therapy of factor VIII inhibitors

M. B. Hultin, S. S. Shapiro, H. S. Bowman, F. M. Gill, A. T. Andrews, J. Martinez, E. M. Eyster, W. C. Sherwood

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations


    Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibitors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.

    Original languageEnglish (US)
    Pages (from-to)95-108
    Number of pages14
    JournalUnknown Journal
    Issue number1
    StatePublished - 1976

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology


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