Immunosuppressive therapy of factor VIII inhibitors

M. B. Hultin, S. S. Shapiro, H. S. Bowman, F. M. Gill, A. T. Andrews, J. Martinez, M. Elaine Eyster, W. C. Sherwood

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibitors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.

    Original languageEnglish (US)
    Pages (from-to)95-108
    Number of pages14
    JournalBlood
    Volume48
    Issue number1
    StatePublished - Dec 1 1976

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    Factor VIII
    Immunosuppressive Agents
    Patient treatment
    Cyclophosphamide
    Therapeutics

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

    Cite this

    Hultin, M. B., Shapiro, S. S., Bowman, H. S., Gill, F. M., Andrews, A. T., Martinez, J., ... Sherwood, W. C. (1976). Immunosuppressive therapy of factor VIII inhibitors. Blood, 48(1), 95-108.
    Hultin, M. B. ; Shapiro, S. S. ; Bowman, H. S. ; Gill, F. M. ; Andrews, A. T. ; Martinez, J. ; Eyster, M. Elaine ; Sherwood, W. C. / Immunosuppressive therapy of factor VIII inhibitors. In: Blood. 1976 ; Vol. 48, No. 1. pp. 95-108.
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    author = "Hultin, {M. B.} and Shapiro, {S. S.} and Bowman, {H. S.} and Gill, {F. M.} and Andrews, {A. T.} and J. Martinez and Eyster, {M. Elaine} and Sherwood, {W. C.}",
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    Hultin, MB, Shapiro, SS, Bowman, HS, Gill, FM, Andrews, AT, Martinez, J, Eyster, ME & Sherwood, WC 1976, 'Immunosuppressive therapy of factor VIII inhibitors', Blood, vol. 48, no. 1, pp. 95-108.

    Immunosuppressive therapy of factor VIII inhibitors. / Hultin, M. B.; Shapiro, S. S.; Bowman, H. S.; Gill, F. M.; Andrews, A. T.; Martinez, J.; Eyster, M. Elaine; Sherwood, W. C.

    In: Blood, Vol. 48, No. 1, 01.12.1976, p. 95-108.

    Research output: Contribution to journalArticle

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    AU - Hultin, M. B.

    AU - Shapiro, S. S.

    AU - Bowman, H. S.

    AU - Gill, F. M.

    AU - Andrews, A. T.

    AU - Martinez, J.

    AU - Eyster, M. Elaine

    AU - Sherwood, W. C.

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    AB - Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibitors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.

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    Hultin MB, Shapiro SS, Bowman HS, Gill FM, Andrews AT, Martinez J et al. Immunosuppressive therapy of factor VIII inhibitors. Blood. 1976 Dec 1;48(1):95-108.