Immunotherapy of tularemia: Characterization of a monoclonal antibody reactive with Francisella tularensis

R. B. Narayanan, Joseph Drabick, J. C. Williams, A. H. Fortier, M. S. Meltzer, J. C. Sadoff, C. R. Bolt, C. A. Nacy

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalJournal of Leukocyte Biology
Volume53
Issue number1
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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    Narayanan, R. B., Drabick, J., Williams, J. C., Fortier, A. H., Meltzer, M. S., Sadoff, J. C., Bolt, C. R., & Nacy, C. A. (1993). Immunotherapy of tularemia: Characterization of a monoclonal antibody reactive with Francisella tularensis. Journal of Leukocyte Biology, 53(1), 112-116. https://doi.org/10.1002/jlb.53.1.112