Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas

R. Grant Muller; Chelsea S. Hamill; Brandon Vu; Jason Thuener; Jay Wasman; Shawn Li; Nicole Fowler; Rod Rezaee; Pierre Lavertu; Min Yao; Kyunghee Burkitt; Jennifer Dorth; Theodoros N. Teknos; Quintin Pan; W. Quinn O'Neill

doi:10.1016/j.oraloncology.2022.105861

Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas

R. Grant Muller, Chelsea S. Hamill, Brandon Vu, Jason Thuener, Jay Wasman, Shawn Li, Nicole Fowler, Rod Rezaee, Pierre Lavertu, Min Yao, Kyunghee Burkitt, Jennifer Dorth, Theodoros N. Teknos, Quintin Pan, W. Quinn O'Neill

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.

Original language	English (US)
Article number	105861
Journal	Oral Oncology
Volume	128
DOIs	https://doi.org/10.1016/j.oraloncology.2022.105861
State	Published - May 2022

All Science Journal Classification (ASJC) codes

Oral Surgery
Oncology
Cancer Research

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Muller, R. G., Hamill, C. S., Vu, B., Thuener, J., Wasman, J., Li, S., Fowler, N., Rezaee, R., Lavertu, P., Yao, M., Burkitt, K., Dorth, J., Teknos, T. N., Pan, Q., & O'Neill, W. Q. (2022). Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas. Oral Oncology, 128, [105861]. https://doi.org/10.1016/j.oraloncology.2022.105861

@article{4b1765c784004f7a91c29148bf877e4b,

title = "Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas",

abstract = "Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.",

author = "Muller, {R. Grant} and Hamill, {Chelsea S.} and Brandon Vu and Jason Thuener and Jay Wasman and Shawn Li and Nicole Fowler and Rod Rezaee and Pierre Lavertu and Min Yao and Kyunghee Burkitt and Jennifer Dorth and Teknos, {Theodoros N.} and Quintin Pan and O'Neill, {W. Quinn}",

note = "Funding Information: Research reported in this publication was supported, in part, by the National Institute of Craniofacial and Dental Research and the National Cancer Institute of the National Institutes of Health under award numbers R01DE023555 and R01CA193590, and University Hospitals Seidman Cancer Center. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = may,

doi = "10.1016/j.oraloncology.2022.105861",

language = "English (US)",

volume = "128",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Limited",

}

Muller, RG, Hamill, CS, Vu, B, Thuener, J, Wasman, J, Li, S, Fowler, N, Rezaee, R, Lavertu, P, Yao, M, Burkitt, K, Dorth, J, Teknos, TN, Pan, Q & O'Neill, WQ 2022, 'Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas', Oral Oncology, vol. 128, 105861. https://doi.org/10.1016/j.oraloncology.2022.105861

TY - JOUR

T1 - Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas

AU - Muller, R. Grant

AU - Hamill, Chelsea S.

AU - Vu, Brandon

AU - Thuener, Jason

AU - Wasman, Jay

AU - Li, Shawn

AU - Fowler, Nicole

AU - Rezaee, Rod

AU - Lavertu, Pierre

AU - Yao, Min

AU - Burkitt, Kyunghee

AU - Dorth, Jennifer

AU - Teknos, Theodoros N.

AU - Pan, Quintin

AU - O'Neill, W. Quinn

N1 - Funding Information: Research reported in this publication was supported, in part, by the National Institute of Craniofacial and Dental Research and the National Cancer Institute of the National Institutes of Health under award numbers R01DE023555 and R01CA193590, and University Hospitals Seidman Cancer Center. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/5

Y1 - 2022/5

N2 - Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.

AB - Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.

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DO - 10.1016/j.oraloncology.2022.105861

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SN - 1368-8375

VL - 128

JO - Oral Oncology

JF - Oral Oncology

M1 - 105861

ER -

Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas

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