TY - JOUR
T1 - Impact of Different Perfusion Modalities on Coronary and Carotid Blood Flow Velocities in an Adult ECLS Swine Model
AU - Wang, Shigang
AU - Patel, Sunil
AU - Izer, Jenelle
AU - Clark, Joseph
AU - Kunselman, Allen
AU - Wilson, Ronald
AU - Undar, Akif
N1 - Funding Information:
We would also like to thank the technicians and residents from the Department of Comparative Medicine for their time and efforts to contribute to this project. Special thanks go to Linda Pauliks, MD, MPH, for technical assistance. This project was supported by a contract between the Xenios AG, Germany and Penn State College of Medicine (contract #140678), Hershey, PA, USA and two additional grants from the Children's Miracle Network, and Penn State College of Medicine, Department of Pediatrics, Division of Cardiology Fellowship Funds.
Funding Information:
Acknowledgments: We would also like to thank the technicians and residents from the Department of Comparative Medicine for their time and efforts to contribute to this project. Special thanks go to Linda Pauliks, MD, MPH, for technical assistance. This project was supported by a contract between the Xenios AG, Germany and Penn State College of Medicine (contract #140678), Hershey, PA, USA and two additional grants from the Children’s Miracle Network, and Penn State College of Medicine, Department of Pediatrics, Division of Cardiology Fellowship Funds.
Publisher Copyright:
© 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
PY - 2018/9
Y1 - 2018/9
N2 - The objective of this study was to compare the effects of nonpulsatile and ECG-synchronized pulsatile extracorporeal life support on coronary and carotid blood flow velocities using transthoracic echocardiography and vascular ultrasound, respectively. Nine adult swine were randomly separated into nonpulsatile (NP, n = 5) and pulsatile (P, N = 4) groups and placed on ECLS for 24 h using an i-cor ECLS system. Noninvasive transthoracic images of the left and right coronary artery and the left carotid artery were acquired at the pre-ECLS (baseline), 30 min, 3, 6, 9, 12, and 24 h on-ECLS stages. The mean diastolic velocity of the left and right coronary arteries in the NP group significantly decreased after 24 h on ECLS compared to the baseline and 30 min ECLS stages (P < 0.05). There was no statistical difference in the mean diastolic velocity of the coronary arteries in the P group at 30 min, 3-, 6-, 9-, 12-, and 24-h ECLS compared to baseline. The P group showed a smaller decrease in the mean diastolic velocity of coronary arteries between the 30-min ECLS and 3-, 6-, 9-, 13-, 24-h ECLS stages compared to the NP group. The diastolic velocity of the left carotid artery in the NP group significantly decreased during 24-h ECLS compared to the P group (P < 0.05). An ECG-synchronized pulsatile ECLS system appeared to maintain coronary and carotid artery diastolic velocities better than conventional nonpulsatile ECLS. Further investigation of the perfusion modes during ECLS is warranted.
AB - The objective of this study was to compare the effects of nonpulsatile and ECG-synchronized pulsatile extracorporeal life support on coronary and carotid blood flow velocities using transthoracic echocardiography and vascular ultrasound, respectively. Nine adult swine were randomly separated into nonpulsatile (NP, n = 5) and pulsatile (P, N = 4) groups and placed on ECLS for 24 h using an i-cor ECLS system. Noninvasive transthoracic images of the left and right coronary artery and the left carotid artery were acquired at the pre-ECLS (baseline), 30 min, 3, 6, 9, 12, and 24 h on-ECLS stages. The mean diastolic velocity of the left and right coronary arteries in the NP group significantly decreased after 24 h on ECLS compared to the baseline and 30 min ECLS stages (P < 0.05). There was no statistical difference in the mean diastolic velocity of the coronary arteries in the P group at 30 min, 3-, 6-, 9-, 12-, and 24-h ECLS compared to baseline. The P group showed a smaller decrease in the mean diastolic velocity of coronary arteries between the 30-min ECLS and 3-, 6-, 9-, 13-, 24-h ECLS stages compared to the NP group. The diastolic velocity of the left carotid artery in the NP group significantly decreased during 24-h ECLS compared to the P group (P < 0.05). An ECG-synchronized pulsatile ECLS system appeared to maintain coronary and carotid artery diastolic velocities better than conventional nonpulsatile ECLS. Further investigation of the perfusion modes during ECLS is warranted.
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U2 - 10.1111/aor.13141
DO - 10.1111/aor.13141
M3 - Article
C2 - 29660857
AN - SCOPUS:85045708714
VL - 42
SP - 918
EP - 921
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 9
ER -