Impact of Humidification Systems on Ventilator-associated Pneumonia a Randomized Multicenter Trial

Jean Claude Lacherade, Marc Auburtin, Charles Cerf, Andry Van De Louw, Lilia Soufir, Yves Rebufat, Saïda Rezaiguia, Jean Damien Ricard, François Lellouche, Christian Brun-Buisson, Laurent Brochard

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Rationale and objectives: The respective influence on the incidence of ventilator-associated pneumonia of currently available systems used for warming and humidifying the gases delivered to mechanically ventilated patients, that is, heated humidifiers and heat and moisture exchanger filters, remains controversial. Methods: We addressed this question in a multicenter randomized study comparing heated humidifiers (with heated circuits) and filters in an unselected population of 369 intensive care patients receiving mechanical ventilation for more than 48 h. Main Measurements and Results: The diagnosis of pneumonia was confirmed according to strict microbiologic criteria. There was no difference in pneumonia rate between the two groups (53 of 184 [28.8%] versus 47 of 185 [25.4%] for humidifiers versus filters; p = 0.48), or in the incidence density of pneumonia (27.4/1,000 ventilatory days versus 25.3/1,000 ventilatory days for humidifiers versus filters; p = 0.76). The mean duration of mechanical ventilation did not differ between the two groups (14.9 ± 15.1 versus 13.5 ± 16.3 days for humidifiers versus filters, p = 0.36). Endotracheal tube occlusion occurred, respectively, in five patients and one patient in the humidifier and filter groups (p = 0.12). Intensive care mortality was identical in the two groups (about 33%). Conclusion: These results suggest that both heated humidifiers and heat and moisture exchanger filters can be used with no significant impact on the incidence of ventilator-associated pneumonia and that other criteria may justify their choice.

Original languageEnglish (US)
Pages (from-to)1276-1282
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume172
Issue number10
DOIs
StatePublished - Nov 15 2005

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Impact of Humidification Systems on Ventilator-associated Pneumonia a Randomized Multicenter Trial'. Together they form a unique fingerprint.

  • Cite this

    Lacherade, J. C., Auburtin, M., Cerf, C., Van De Louw, A., Soufir, L., Rebufat, Y., Rezaiguia, S., Ricard, J. D., Lellouche, F., Brun-Buisson, C., & Brochard, L. (2005). Impact of Humidification Systems on Ventilator-associated Pneumonia a Randomized Multicenter Trial. American journal of respiratory and critical care medicine, 172(10), 1276-1282. https://doi.org/10.1164/rccm.200408-1028OC