Impact of inodilator drugs on echocardiographic assessments of left ventricular filling pressure in patients with decompensated end-stage heart failure

Joe Elie Salem, Nadia Aissaoui, Lech Paluszkiewicz, Michiel Morshuis, Jan Gummert, Pascal Leprince, Jean Yves Fagon, Jean Sébastien Hulot, Benoit Diebold

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Abstract

Objectives: We investigated the impact of inodilators on the accuracy of E/e' ratio as a surrogate for pulmonary artery occlusion pressure in patients with decompensated end-stage systolic heart failure. Setting: The ratio of early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity, E/e', and pulmonary artery occlusion pressure have been shown to be correlated. The validity of E/e' for predicting pulmonary artery occlusion pressure in patients with decompensated end-stage systolic heart failure was recently challenged, but the influence of inodilators was not taken into account, despite the reported influence of these drugs on left ventricular relaxation properties. Patients and Intervention: Invasive hemodynamic monitoring and echocardiographic data were collected prospectively from 39 patients with decompensated end-stage systolic heart failure (92% male), aged 56 ± 13 years. These patients had dilated ventricles with a low cardiac index (1.9 ± 0.6 L/min/m2) and high pulmonary artery occlusion pressure (22 ± 8 mm Hg), and 90% required inodilator support during hospitalization. Measurements and Main Results: The correlation between septal E/e' and pulmonary artery occlusion pressure was good for examinations in the absence of inodilators (n = 21) (r = 0.7; p < 0.001), but no correlation was found when inodilators were used (n = 31). Lateral and mean E/e' were poorly correlated with pulmonary artery occlusion pressure, if at all, in both cases. Conclusions: By modifying ventricular relaxation properties and the influence of filling pressure on e', inodilator agents severely impair the correlation between E/e' and pulmonary artery occlusion pressure in patients with decompensated end-stage systolic heart failure.

Original languageEnglish (US)
Pages (from-to)2508-2517
Number of pages10
JournalCritical care medicine
Volume42
Issue number12
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

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    Salem, J. E., Aissaoui, N., Paluszkiewicz, L., Morshuis, M., Gummert, J., Leprince, P., Fagon, J. Y., Hulot, J. S., & Diebold, B. (2014). Impact of inodilator drugs on echocardiographic assessments of left ventricular filling pressure in patients with decompensated end-stage heart failure. Critical care medicine, 42(12), 2508-2517. https://doi.org/10.1097/CCM.0000000000000513