Impact of oxidative stress on female fertility

Elizabeth H. Ruder, Terryl Johnson Hartman, Marlene B. Goldman

Research output: Contribution to journalReview article

102 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: To review the role of oxidative stress in the context of female fertility. RECENT FINDINGS: Oxidative stress is associated with decreased female fertility in animal and in-vitro models, but no studies to date have directly assessed the relationship in women. Exposures associated with oxidative stress and with evidence to influence the timing and maintenance of a viable pregnancy include pregnancy complications (e.g. preeclampsia), extremes of body weight, alcohol, tobacco, and caffeine intake. Intake of antioxidant nutrients, including use of multivitamins, impacts the generation of reactive oxygen species and may play a beneficial role in female fertility. SUMMARY: Infertility is a significant public health problem and diagnosis and treatment are stressful, invasive, and costly. The role of oxidative stress in female fertility is an understudied and compelling area for investigation. Identifying modifiable factors to decrease oxidative stress in the gynecologic environment may be an inexpensive and noninvasive therapy for increasing fertility.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalCurrent Opinion in Obstetrics and Gynecology
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2009

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Fertility
Oxidative Stress
Pregnancy Complications
Pre-Eclampsia
Caffeine
Infertility
Tobacco
Reactive Oxygen Species
Public Health
Antioxidants
Body Weight
Maintenance
Alcohols
Food
Pregnancy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Ruder, Elizabeth H. ; Hartman, Terryl Johnson ; Goldman, Marlene B. / Impact of oxidative stress on female fertility. In: Current Opinion in Obstetrics and Gynecology. 2009 ; Vol. 21, No. 3. pp. 219-222.
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Impact of oxidative stress on female fertility. / Ruder, Elizabeth H.; Hartman, Terryl Johnson; Goldman, Marlene B.

In: Current Opinion in Obstetrics and Gynecology, Vol. 21, No. 3, 01.06.2009, p. 219-222.

Research output: Contribution to journalReview article

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