Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures

Tijen Alkan-Bozkaya, Atif Akçevin, Halil Türkoǧlu, Akif Undar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
JournalArtificial organs
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Pulsatile Flow
Pathology
Cardiopulmonary Bypass
Transposition of Great Vessels
Pediatrics
Ventricular Heart Septal Defects
Newborn Infant
Defects
Repair
Urine
Pulsatile flow
Intensive care units
Congenital Heart Defects
Surgery
Thoracic Surgery
Albumins
Lactic Acid
Length of Stay
Perfusion
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

@article{fe31fe663ef74d6d90847909b217c884,
title = "Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures",
abstract = "The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.",
author = "Tijen Alkan-Bozkaya and Atif Ak{\cc}evin and Halil T{\"u}rkoǧlu and Akif Undar",
year = "2013",
month = "1",
day = "1",
doi = "10.1111/j.1525-1594.2012.01552.x",
language = "English (US)",
volume = "37",
pages = "82--86",
journal = "Artificial Organs",
issn = "0160-564X",
publisher = "Wiley-Blackwell",
number = "1",

}

Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures. / Alkan-Bozkaya, Tijen; Akçevin, Atif; Türkoǧlu, Halil; Undar, Akif.

In: Artificial organs, Vol. 37, No. 1, 01.01.2013, p. 82-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures

AU - Alkan-Bozkaya, Tijen

AU - Akçevin, Atif

AU - Türkoǧlu, Halil

AU - Undar, Akif

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.

AB - The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.

UR - http://www.scopus.com/inward/record.url?scp=84872404314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872404314&partnerID=8YFLogxK

U2 - 10.1111/j.1525-1594.2012.01552.x

DO - 10.1111/j.1525-1594.2012.01552.x

M3 - Article

C2 - 23145894

AN - SCOPUS:84872404314

VL - 37

SP - 82

EP - 86

JO - Artificial Organs

JF - Artificial Organs

SN - 0160-564X

IS - 1

ER -