Impact of transgenic technologies on functional genomics

Cooduvalli S. Shashikant, Frank H. Ruddle

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Gene transfer technologies in mammals are the focus of renewed interest owing to the recent emphasis on analyzing gene function in the postgenomic era. Three important developments in this area include transgenics, gene targeting and nuclear transfer or animal cloning. These technological innovations have enhanced our ability to analyze gene function at the level of the whole organism and have provided the means to modify gene expression. This review discusses the origins and current status of transgenic technologies. Various applications and technologies including chromosome engineering, stem cells, gene traps and modification of livestock are presented. The impact of mouse technologies and genomics on functional analyses is also discussed.

Original languageEnglish (US)
Pages (from-to)75-98
Number of pages24
JournalCurrent Issues in Molecular Biology
Volume5
Issue number3
StatePublished - Jul 1 2003

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Microbiology (medical)

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