Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients with Peripheral Artery Disease

Andrew W. Gardner, Donald E. Parker, Polly S. Montgomery, Danuta Sosnowska, Ana I. Casanegra, Omar L. Esponda, Zoltan Ungvari, Anna Csiszar, William E. Sonntag

Research output: Contribution to journalArticle

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Abstract

We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 130 patients with peripheral artery disease (PAD) and a control group of 36 patients with high burden of comorbid conditions and cardiovascular risk factors. Second, we compared circulating inflammatory, antioxidant capacity, and vascular biomarkers between the groups. The groups were not significantly different (P >.05) on apoptosis, hydrogen peroxide, hydroxyl radical antioxidant capacity, and nuclear factor κ-light-chain enhancer of activated B cells. Circulating tumor necrosis factor α (TNF-α; P =.016) and interleukin 8 (IL-8; P =.006) were higher in the PAD group, whereas vascular endothelial growth factor A (VEGF-A; P =.023) was lower. The PAD does not impair the endothelium beyond that which already occurs from comorbid conditions and cardiovascular risk factors in patients with claudication. However, patients with PAD have lower circulating VEGF-A than the control group and higher circulating inflammatory parameters of TNF-α and IL-8.

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
JournalAngiology
Volume65
Issue number8
DOIs
StatePublished - Sep 2014

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Peripheral Arterial Disease
Vascular Endothelial Growth Factor A
Interleukin-8
Inflammation
Antioxidants
Apoptosis
Control Groups
Hydroxyl Radical
Hydrogen Peroxide
Endothelium
Blood Vessels
Cultured Cells
Oxidative Stress
B-Lymphocytes
Endothelial Cells
Tumor Necrosis Factor-alpha
Biomarkers
Light
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Gardner, A. W., Parker, D. E., Montgomery, P. S., Sosnowska, D., Casanegra, A. I., Esponda, O. L., ... Sonntag, W. E. (2014). Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients with Peripheral Artery Disease. Angiology, 65(8), 683-690. https://doi.org/10.1177/0003319713501376
Gardner, Andrew W. ; Parker, Donald E. ; Montgomery, Polly S. ; Sosnowska, Danuta ; Casanegra, Ana I. ; Esponda, Omar L. ; Ungvari, Zoltan ; Csiszar, Anna ; Sonntag, William E. / Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients with Peripheral Artery Disease. In: Angiology. 2014 ; Vol. 65, No. 8. pp. 683-690.
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Gardner, AW, Parker, DE, Montgomery, PS, Sosnowska, D, Casanegra, AI, Esponda, OL, Ungvari, Z, Csiszar, A & Sonntag, WE 2014, 'Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients with Peripheral Artery Disease', Angiology, vol. 65, no. 8, pp. 683-690. https://doi.org/10.1177/0003319713501376

Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients with Peripheral Artery Disease. / Gardner, Andrew W.; Parker, Donald E.; Montgomery, Polly S.; Sosnowska, Danuta; Casanegra, Ana I.; Esponda, Omar L.; Ungvari, Zoltan; Csiszar, Anna; Sonntag, William E.

In: Angiology, Vol. 65, No. 8, 09.2014, p. 683-690.

Research output: Contribution to journalArticle

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AU - Parker, Donald E.

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AU - Casanegra, Ana I.

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AU - Csiszar, Anna

AU - Sonntag, William E.

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