TY - JOUR
T1 - Imperfect vaccine-induced immunity and whooping cough transmission to infants
AU - Lavine, Jennie
AU - Broutin, Hélène
AU - Harvill, Eric T.
AU - Bjørnstad, Ottar N.
N1 - Funding Information:
This work was funded from the Bill and Melinda Gates Foundation (ONB), the RAPIDD program of the Science & Technology Directorate (ONB), the National Institute of Health (ONB; grant NIH/GM R01-GM083983-01, ONB and ETH; grants NIH/NIAID R56-AI065507-01A2 and NIH/GM R01-GM083113-01), NSF GREATT fellowship (JL) and the intramural Research Group at Fogarty International Center, at the NIH (HB).
PY - 2010/12/10
Y1 - 2010/12/10
N2 - Whooping cough, caused by B. pertussis and B. parapertussis, has increased in incidence throughout much of the developed world since the 1980s despite high vaccine coverage, causing an increased risk of infection in infants who have substantial disease-induced mortality. Duration of immunity and epidemically significant routes of transmission across age groups remain unclear and deserve further investigation to inform vaccination strategies to better control pertussis burden. The authors analyze age- and species-specific whooping cough tests and vaccine histories in Massachusetts from 1990 to 2008. On average, the disease-free duration is 10.5 years. However, it has been decreasing over time, possibly due to a rising force of infection through increased circulation. Despite the importance of teenage cases during epidemics, wavelet analyses suggest that they are not the most important source of transmission to infants. In addition, the data indicate that the B. pertussis vaccine is not protective against disease induced by B. parapertussis.
AB - Whooping cough, caused by B. pertussis and B. parapertussis, has increased in incidence throughout much of the developed world since the 1980s despite high vaccine coverage, causing an increased risk of infection in infants who have substantial disease-induced mortality. Duration of immunity and epidemically significant routes of transmission across age groups remain unclear and deserve further investigation to inform vaccination strategies to better control pertussis burden. The authors analyze age- and species-specific whooping cough tests and vaccine histories in Massachusetts from 1990 to 2008. On average, the disease-free duration is 10.5 years. However, it has been decreasing over time, possibly due to a rising force of infection through increased circulation. Despite the importance of teenage cases during epidemics, wavelet analyses suggest that they are not the most important source of transmission to infants. In addition, the data indicate that the B. pertussis vaccine is not protective against disease induced by B. parapertussis.
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U2 - 10.1016/j.vaccine.2010.10.029
DO - 10.1016/j.vaccine.2010.10.029
M3 - Article
C2 - 21034823
AN - SCOPUS:78649692659
VL - 29
SP - 11
EP - 16
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 1
ER -