Implementing individualized medicine into the medical practice

Konstantinos N. Lazaridis, Tammy M. MCAllister, Dusica Babovic-Vuksanovic, Scott A. Beck, Mitesh J. Borad, Alan H. Bryce, Asher A. Chanan-Khan, Matthew J. Ferber, Rafael Fonseca, Kiley J. Johnson, Eric W. Klee, Noralane M. Lindor, Jennifer McCormick, Robert R. MCWilliams, Alexander S. Parker, Douglas L. Riegert-Johnson, Carolyn R. Rohrer Vitek, Kimberly A. Schahl, Cloann Schultz, Keith StewartGeorge C. Then, Eric D. Wieben, Gianrico Farrugia

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume166
Issue number1
DOIs
StatePublished - Jan 1 2014

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Precision Medicine
Medicine
Patient Care
Exome
Workflow
Evidence-Based Medicine
Genomics
Technology
Costs and Cost Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Lazaridis, K. N., MCAllister, T. M., Babovic-Vuksanovic, D., Beck, S. A., Borad, M. J., Bryce, A. H., ... Farrugia, G. (2014). Implementing individualized medicine into the medical practice. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 166(1), 15-23. https://doi.org/10.1002/ajmg.c.31387
Lazaridis, Konstantinos N. ; MCAllister, Tammy M. ; Babovic-Vuksanovic, Dusica ; Beck, Scott A. ; Borad, Mitesh J. ; Bryce, Alan H. ; Chanan-Khan, Asher A. ; Ferber, Matthew J. ; Fonseca, Rafael ; Johnson, Kiley J. ; Klee, Eric W. ; Lindor, Noralane M. ; McCormick, Jennifer ; MCWilliams, Robert R. ; Parker, Alexander S. ; Riegert-Johnson, Douglas L. ; Rohrer Vitek, Carolyn R. ; Schahl, Kimberly A. ; Schultz, Cloann ; Stewart, Keith ; Then, George C. ; Wieben, Eric D. ; Farrugia, Gianrico. / Implementing individualized medicine into the medical practice. In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2014 ; Vol. 166, No. 1. pp. 15-23.
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Lazaridis, KN, MCAllister, TM, Babovic-Vuksanovic, D, Beck, SA, Borad, MJ, Bryce, AH, Chanan-Khan, AA, Ferber, MJ, Fonseca, R, Johnson, KJ, Klee, EW, Lindor, NM, McCormick, J, MCWilliams, RR, Parker, AS, Riegert-Johnson, DL, Rohrer Vitek, CR, Schahl, KA, Schultz, C, Stewart, K, Then, GC, Wieben, ED & Farrugia, G 2014, 'Implementing individualized medicine into the medical practice', American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, vol. 166, no. 1, pp. 15-23. https://doi.org/10.1002/ajmg.c.31387

Implementing individualized medicine into the medical practice. / Lazaridis, Konstantinos N.; MCAllister, Tammy M.; Babovic-Vuksanovic, Dusica; Beck, Scott A.; Borad, Mitesh J.; Bryce, Alan H.; Chanan-Khan, Asher A.; Ferber, Matthew J.; Fonseca, Rafael; Johnson, Kiley J.; Klee, Eric W.; Lindor, Noralane M.; McCormick, Jennifer; MCWilliams, Robert R.; Parker, Alexander S.; Riegert-Johnson, Douglas L.; Rohrer Vitek, Carolyn R.; Schahl, Kimberly A.; Schultz, Cloann; Stewart, Keith; Then, George C.; Wieben, Eric D.; Farrugia, Gianrico.

In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, Vol. 166, No. 1, 01.01.2014, p. 15-23.

Research output: Contribution to journalArticle

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T1 - Implementing individualized medicine into the medical practice

AU - Lazaridis, Konstantinos N.

AU - MCAllister, Tammy M.

AU - Babovic-Vuksanovic, Dusica

AU - Beck, Scott A.

AU - Borad, Mitesh J.

AU - Bryce, Alan H.

AU - Chanan-Khan, Asher A.

AU - Ferber, Matthew J.

AU - Fonseca, Rafael

AU - Johnson, Kiley J.

AU - Klee, Eric W.

AU - Lindor, Noralane M.

AU - McCormick, Jennifer

AU - MCWilliams, Robert R.

AU - Parker, Alexander S.

AU - Riegert-Johnson, Douglas L.

AU - Rohrer Vitek, Carolyn R.

AU - Schahl, Kimberly A.

AU - Schultz, Cloann

AU - Stewart, Keith

AU - Then, George C.

AU - Wieben, Eric D.

AU - Farrugia, Gianrico

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Lazaridis KN, MCAllister TM, Babovic-Vuksanovic D, Beck SA, Borad MJ, Bryce AH et al. Implementing individualized medicine into the medical practice. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2014 Jan 1;166(1):15-23. https://doi.org/10.1002/ajmg.c.31387