Improved Mathematical Model of APA Microcapsules

Yang He, Yu Bing Xie, Yong Wang, Qun Liu, Xiao Jun Ma

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


It is essential to investigate the diffusion characteristics of alginate-polylysine-alginate(APA) microcapsule system for its broad applications. An advanced mathematical model for protein diffusion in APA microcapsules is established, which presents the resistance coefficient of microcapsule membrane and distribution coefficient in microcapsule matrix. These two parameters as the important basis of optimizing preparation and directing application of microcapsule are determined by the measurement of the protein concentration in the extracapsular solution. With assistance of mathmatical model, membrane diffusion characteristics affected by reaction time in membrane forming are analyzed: (1) microcapsule shows greater resistance constant and distribution constant to the diffusion of protein with greater molecular weight, (2) prologation reaction time results in increase in resistance constant and distribut constant of microcapsule.

Original languageEnglish (US)
Pages (from-to)282
Number of pages1
JournalKao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Issue number2
StatePublished - Feb 10 2000

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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