Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp 2)-H amination

Gang He, Chengxi Lu, Yingsheng Zhao, William A. Nack, Gong Chen

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp 2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

Original languageEnglish (US)
Pages (from-to)2944-2947
Number of pages4
JournalOrganic Letters
Volume14
Issue number12
DOIs
StatePublished - Jun 15 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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