Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition

Vikas Gulani, Thomas Weber, Thomas Neuberger, Andrew G. Webb

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.

Original languageEnglish (US)
Pages (from-to)329-335
Number of pages7
JournalJournal of Magnetic Resonance
Volume177
Issue number2
DOIs
StatePublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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